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TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury.
Sci Rep
January 2025
Division of Anaesthesia, University of Cambridge, Cambridge, UK.
Practices for controlling intracranial pressure (ICP) in traumatic brain injury (TBI) patients admitted to the intensive care unit (ICU) vary considerably between centres. To help understand the rational basis for such variance in care, this study aims to identify the patient-level predictors of changes in ICP management. We extracted all heterogeneous data (2008 pre-ICU and ICU variables) collected from a prospective cohort (n = 844, 51 ICUs) of ICP-monitored TBI patients in the Collaborative European NeuroTrauma Effectiveness Research in TBI study.
View Article and Find Full Text PDFMonte Carlo in the mechanistic modelling of the FLASH effect: a review.
Phys Med Biol
January 2025
Physics, The University of Western Australia, 35 Stirling Highway, Mailbag M013, WA 6009, Perth, 6009, AUSTRALIA.
FLASH radiotherapy employs ultra-high dose rates of >40 Gy/s, which may reduce normal tissue complication as compared to conventional dose rate treatments, while still ensuring the same level of tumour control. The potential benefit this can offer to patients has been the cause of great interest within the radiation oncology community, but this has not translated to a direct understanding of the FLASH effect. The oxygen depletion and inter-track interaction hypotheses are currently the leading explanations as to the mechanisms behind FLASH, but these are still not well understood, with many questions remaining about the exact underpinnings of FLASH and the treatment parameters required to optimally induce it.
View Article and Find Full Text PDFMechanistic Insights into the Divergent Membrane Activities of a Viroporin from Chikungunya Virus and Its Transframe Variant.
ACS Infect Dis
January 2025
Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Alphaviruses, a genus of vector-borne viruses in the family, encode a small ion-channel-forming protein, 6K, and its transframe variant (TF) during infections. Although 6K/TF have vital roles in glycoprotein transport, virus assembly, and budding, there is no mechanistic explanation for these functions. We investigated the distinct biochemical functionalities of 6K and TF from the mosquito-borne alphavirus, Chikungunya Virus.
View Article and Find Full Text PDFThe Target of Rapamycin kinase is a positive regulator of plant fatty acid and lipid synthesis.
Plant Physiol
December 2024
Department of Biology, BNL 463, 50 Bell Ave, Upton NY 11973, USA.
In eukaryotes, Target of Rapamycin (TOR), a conserved protein sensor kinase, integrates diverse environmental cues, including growth factor signals, energy availability, and nutritional status, to direct cell growth. In plants, TOR is activated by light and sugars and regulates a wide range of cellular processes, including protein synthesis and metabolism. Fatty acid synthesis is key to membrane biogenesis that is required for cell growth.
View Article and Find Full Text PDFNeural mass modeling for the masses: Democratizing access to whole-brain biophysical modeling with FastDMF.
Netw Neurosci
December 2024
Institucio Catalana de la Recerca i Estudis Avancats (ICREA), Barcelona, Spain.
Different whole-brain computational models have been recently developed to investigate hypotheses related to brain mechanisms. Among these, the Dynamic Mean Field (DMF) model is particularly attractive, combining a biophysically realistic model that is scaled up via a mean-field approach and multimodal imaging data. However, an important barrier to the widespread usage of the DMF model is that current implementations are computationally expensive, supporting only simulations on brain parcellations that consider less than 100 brain regions.
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