Outpatient parenteral antibiotic treatment for infective endocarditis: A retrospective observational evaluation.

Clin Med (Lond)

Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds, England, United Kingdom; Leeds Institute of Medical Research, University of Leeds, Leeds, England, United Kingdom.

Published: May 2024

Background: Infective endocarditis (IE) requires long courses of intravenous (IV) antibiotics. Outpatient parenteral antibiotic therapy (OPAT) saves resources, improves the patient experience and allows care in their preferred place; however, questions remain about safety when treating IE patients. This study evaluates OPAT management of IE patients in our region between 2006 and 2019.

Methods: This is a retrospective observational evaluation and description of outcomes and adherence to suitability criteria, according to British Society for Antimicrobial Chemotherapy (BSAC) guidelines.

Results: We identified five models of OPAT delivery. The number of patients treated expanded significantly over time. Of 101 patients, six (6%) suffered poor outcomes, but each patient had contributing factors outside of the primary infection. Median OPAT duration was 12 days and 1,489 hospital bed days were saved.

Conclusions: In a setting where there was good adherence to BSAC criteria, treating IE patients using OPAT services was safe. Complications observed were likely independent of treatment location. Significant bed days were saved.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11101910PMC
http://dx.doi.org/10.1016/j.clinme.2024.100213DOI Listing

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