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An evidence-based update on the diagnosis and management of irritable bowel syndrome.
Expert Rev Gastroenterol Hepatol
January 2025
Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.
Introduction: Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction affecting 5% of the population. The cardinal symptoms are abdominal pain and altered stool form or frequency.
Areas Covered: Diagnosis and management of IBS.
Safety and effects of anti-obesity medications on weight loss, cardiometabolic, and psychological outcomes in people living with overweight or obesity: a systematic review and meta-analysis.
EClinicalMedicine
January 2025
National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Overweight and obesity pose serious health challenges for individuals and societies. This study aims to facilitate personalised treatment of obesity by summarising recent research on weight-loss pharmacotherapies, with a focus on their effects on weight reduction, cardiometabolic health, psychological outcomes, and adverse events.
Methods: This systematic review and meta-analysis included searches of Web of Science, PubMed, and Cochrane Central Register of Controlled Trials from inception to June 8, 2024.
Efficacy of Probiotics in the Management of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.
Cureus
December 2024
Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, SAU.
Irritable bowel syndrome (IBS) significantly impacts quality of life. Probiotics offer relief by modulating gut microbiota, but variability in outcomes necessitates a systematic evaluation of their efficacy. This study aims to evaluate the efficacy of probiotics in improving symptoms of IBS through a systematic review and meta-analysis.
View Article and Find Full Text PDFExploring temperament and sleep patterns in disruptive mood dysregulation disorder among children and adolescents: implications for clinical practice.
Nord J Psychiatry
January 2025
Department of Child and Adolescent Psychiatry, Yildirim Beyazit University Yenimahalle Education and Research Hospital, Ankara, Turkey.
Background: Disruptive Mood Dysregulation Disorder (DMDD), characterized by severe irritability and temper outbursts, is a relatively new diagnosis included in the DSM-5. The study aimed to investigate the clinical characteristics, temperament, comorbidities, medication use, and sleep quality of children and adolescents diagnosed with DMDD and compare them with Major Depressive Disorder (MDD).
Methods: A total of 233 participants (DMDD: = 106; MDD: = 127) were assessed using the K-SADS-PL.
Bile acid diarrhea in patients with chronic diarrhea. Current appraisal and recommendations for clinical practice.
Dig Liver Dis
January 2025
Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Milano, Italy. Electronic address:
Bile Acid Diarrhea (BAD) is a common cause of chronic diarrhea, often accompanied by urgency, occasional fecal incontinence, abdominal pain, and fatigue. A nationwide survey has shown limited awareness of BAD within the Italian medical community, prompting a panel of experts to develop a Position Paper that outlines the most practical and cost-saving diagnostic investigations and treatments for this frequently overlooked condition. The document provides an overview of the epidemiology, pathophysiology, clinical manifestations, and classification of the different types of Bile Acid Diarrhea (BAD).
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