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Understanding excess mortality during COVID in Belgium: the influence of pre-existing health status and social factors.
Arch Public Health
January 2025
Solidaris - Socialist Health Insurance Fund, Brussels, Belgium.
Background: This study aims to investigate how pre-existing health status and social background contribute to excess mortality during the COVID-19 crisis in Belgium.
Methods: The study population consists of almost 1.4 million adult members of Solidaris, the second largest health insurance fund in Belgium.
The relationship between spontaneous cystic degeneration and pseudocapillarization in sinusoids in the liver of aged Sprague-Dawley rats.
J Toxicol Pathol
January 2025
The Institute of Environmental Toxicology, 4321 Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan.
Cystic degeneration (CD) in the liver is a cyst-like lesion composed of one or more pseudocysts lacking lining cells, occurring spontaneously in rats older than 12 months, with a male predilection. In this study, 32 CDs were identified in 23 out of 104 non-treated, control male Sprague-Dawley rats from two combined chronic toxicity and carcinogenicity studies with agrochemicals. They were examined histologically, histochemically, and immunohistochemically to assess the pathogenesis and pathological significance of CD, focusing on pseudocapillarization in aged rat liver.
View Article and Find Full Text PDFSociocultural and perinatal health factors associated with Autism spectrum disorder (ASD) in children.
Compr Psychiatry
January 2025
School of Clinical Medicine, University of New South Wales, Sydney, NSW, Australia; Academic Unit of Child Psychiatry, Liverpool Hospital, Liverpool, NSW, Australia; Ingham Institute of Applied Medical Research and Liverpool Hospital, Sydney, NSW, Australia. Electronic address:
While previous research has examined perinatal factors in the context of Autism Spectrum Disorder (ASD), studies focusing on sociocultural factors is limited. We conducted a cross-sectional analysis utilizing data from the Australian Autism Biobank (AAB), which encompasses autistic children aged 2-17, their siblings, parents, and unrelated controls. Employing multivariable regression analyses, we aimed to identify factors associated with ASD across various domains, spanning health and lifestyle, perinatal, and postnatal contexts.
View Article and Find Full Text PDFPhysical function estimates change in pain following IIPT among children with chronic pain.
Pain Pract
February 2025
Inpatient Chronic Pain Management Program, Rady Children's Hospital, San Diego, California, USA.
Introduction: Chronic pain can negatively impact a child's quality of life. Pediatric Intensive Interdisciplinary Pain Treatment (IIPT) programs aim to improve overall functioning despite pain through various rehabilitative strategies. It is, however, unclear whether improved function corresponds to self-reported decrease in pain levels.
View Article and Find Full Text PDFManaging novel therapies and concomitant medications in chronic lymphocytic leukemia: key challenges.
Front Pharmacol
January 2025
Clinic of Hematology, University Clinical Centre of Serbia, Belgrade, Serbia.
The treatment of chronic lymphocytic leukemia (CLL) consists of the continuous use of Bruton tyrosine kinase inhibitors (BTKis) such as ibrutinib, acalabrutinib, zanubrutinib and pirtobrutinib, or Bcl-2 inhibitors, such as venetoclax. Overall survival (OS) and progression-free survival (PFS) of CLL patients are significantly improved with the use of these therapies. Adverse effects (AEs) that can occur during treatment and the presence of pre-existing comorbidities in patients can influence subsequent treatment outcomes and, consequently, OS and PFS.
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