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Approaches for difficult-to-induce-seizures electroconvulsive therapy cases (DEC): a Japanese expert consensus.
Ann Gen Psychiatry
January 2025
Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-Ku, Kumamoto, 860-8556, Japan.
Background: Seizure threshold increases with age and the frequency of electroconvulsive therapy (ECT). Therefore, therapeutic seizures can be difficult to induce, even at maximum stimulus charge with available ECT devices. Such cases are known as difficult-to-induce-seizures electroconvulsive therapy cases (DECs).
View Article and Find Full Text PDFDriving brain state transitions via Adaptive Local Energy Control Model.
Neuroimage
January 2025
College of Computer Science and Technology (College of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China. Electronic address:
The brain, as a complex system, achieves state transitions through interactions among its regions and also performs various functions. An in-depth exploration of brain state transitions is crucial for revealing functional changes in both health and pathological states and realizing precise brain function intervention. Network control theory offers a novel framework for investigating the dynamic characteristics of brain state transitions.
View Article and Find Full Text PDFGenetic variants in COMT and ESR1 genes shape treatment response to raloxifene in schizophrenia-spectrum disorders.
Psychoneuroendocrinology
January 2025
Department of Psychiatry, University Medical Center Groningen, Groningen, the Netherlands.
Background/objective: Raloxifene, a selective estrogen receptor modulator (SERM), may improve symptoms and cognition in schizophrenia spectrum disorders (SSD). Studies have shown inconsistent efficacy, especially in men with SSD. We assessed whether single nucleotide polymorphisms (SNPs) on genes involved in the pharmacodynamics (ESR1 and COMT) and pharmacokinetics (UGT1A8) of raloxifene can explain the heterogeneous treatment response to raloxifene augmentation in patients with SSD.
View Article and Find Full Text PDFA call for greater diversity and representativity within countries in psychiatric research: Lessons and challenges from a systematic review of schizophrenia research in Brazil.
Braz J Psychiatry
January 2025
Departamento de Psiquiatria, Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, Brazil. Laboratório Interdisciplinar de Neurociências Integrativas (LiNC), Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP), São Paulo, SP, Brazil. Programa de Esquizofrenia (PROESQ), Escola Paulista de Medicina, Universidade Federal de São Paulo (EPM/UNIFESP, São Paulo, SP, Brazil.
Objective: This article aims to systematically review the studies on schizophrenia in Brazil, addressing geographical coverage as an indicator of sampling representativeness, essential to infer results' generalization. It also highlights the variation in research funding across different regions.
Methods: We searched for studies carried out until July 2023.
The role of ferroptosis and oxidative stress in cognitive deficits among chronic schizophrenia patients: a multicenter investigation.
Schizophrenia (Heidelb)
January 2025
Xinjiang Clinical Medical Research Center of Mental Health, State Key Laboratory of Pathogenesis, Prevention, and Treatment of High Incidence Diseases in Central Asia, The Psychological Medicine Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Oxidative stress (OS) is crucial in schizophrenia (SCZ) pathology. Ferroptosis, a recently discovered cell death pathway linked to OS, might contribute to the development of SCZ. This study investigated the association between ferroptosis markers and cognitive impairments in chronic SCZ patients.
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