High-pressure homogenization is a widely used and acknowledged method to reduce the particle sizes of active pharmaceutical compounds into nanosized range. Thus, the method is associated with limitations, as the compound's initial particle size, since micronized particles are often prerequired to achieve successful size reduction into nanosized range. In this work, the usage of ultrasound as a potential milling or pre-milling technique to decrease particle sizes of different drug compounds varying in deformation properties into micronized range, was investigated.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.xphs.2024.04.015 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Triboelectric Separation for Protein Enrichment of Wheat Flour Compared with Gluten-Starch Mixtures as a .
Foods
December 2024
Food Process Engineering, TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.
Triboelectric separation, a solvent-free method, was investigated as a tool for protein enrichment in wheat flour. Gluten-starch model mixtures, flour, and reground flour fractions were evaluated for their separation characteristics (selectivity and efficiency). Mass yield, protein content, particle size distribution, and SEM analysis were used to assess performance.
View Article and Find Full Text PDFPotential of Powder Rheology for Detecting Unforeseen Cross-Contamination of Foreign Active Pharmaceutical Ingredients.
AAPS PharmSciTech
June 2024
Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka- shi, Fukuoka, 814-0180, Japan.
Unexpected cross-contamination by foreign components during the manufacturing and quality control of pharmaceutical products poses a serious threat to the stable supply of drugs and the safety of customers. In Japan, in 2020, a mix-up containing a sleeping drug went undetected by liquid chromatography during the final quality test because the test focused only on the main active pharmaceutical ingredient (API) and known impurities. In this study, we assessed the ability of a powder rheometer to analyze powder characteristics in detail to determine whether it can detect the influence of foreign APIs on powder flow.
View Article and Find Full Text PDFPre-milling technique improves the accuracy of posterior femoral condyle cut and reduces the tibial recut in Oxford unicompartmental knee arthroplasty.
Arch Orthop Trauma Surg
June 2024
Department of Orthopaedic Surgery and Joint Surgery Centre, Takatsuki General Hospital, 1-3-13, Kosobe- Cho, Takatsuki City, Osaka, 561-1115, Japan.
Article Synopsis
- A study explored the effectiveness of a pre-milling technique in unicompartmental knee arthroplasty (UKA) to improve posterior tibial cut thickness and reduce the need for recuts.
- The research included 213 knees in a conventional surgery group and 198 knees in a pre-milling group, comparing bone cut thickness and rates of tibial recuts.
- Results showed that the pre-milling technique led to increased bone cut thickness in small and medium femoral components and significantly reduced the rate of tibial recuts compared to the conventional method.
Is Ultrasound as a Milling or Pre-Milling Method to Prepare Aqueous Suspensions an Effective Approach?
J Pharm Sci
July 2024
Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark. Electronic address:
High-pressure homogenization is a widely used and acknowledged method to reduce the particle sizes of active pharmaceutical compounds into nanosized range. Thus, the method is associated with limitations, as the compound's initial particle size, since micronized particles are often prerequired to achieve successful size reduction into nanosized range. In this work, the usage of ultrasound as a potential milling or pre-milling technique to decrease particle sizes of different drug compounds varying in deformation properties into micronized range, was investigated.
View Article and Find Full Text PDFDirect milling: Efficient, facile, and green method for processing fibrillated cellulose/polymeric nanocomposites with boosted thermomechanical and rheological performance.
Carbohydr Polym
August 2023
Department of Chemical and Biological Engineering, BioProducts Institute, University of British Columbia, 2360 East Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:
Bringing biobased nanomaterials into polymer manufacturing is essential to enhance polymers' properties and address the challenges posed by plastic waste. Using polymers such as polyamide 6 (PA6) in advanced industries, e.g.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!