AI Article Synopsis
- The study investigates how tacrolimus affects proteinuria in patients suffering from idiopathic membranous nephropathy (IMN), using a machine learning model for analysis.
- Data collected from existing literature and 463 IMN patients was analyzed to determine the drug's effectiveness based on changes in proteinuria levels.
- Results indicate that to achieve optimal therapeutic effects, tacrolimus concentrations should be maintained within the range of 4-10 ng/ml for a minimum of 1.72 months.
Article Abstract
Purpose: The present study aims to explore the effects of tacrolimus on proteinuria in patients with idiopathic membranous nephropathy (IMN) and recommend an appropriate dosage schedule via machine learning method.
Methods: The E model was constructed to analyze the effects of tacrolimus on proteinuria in patients with IMN. Data were mined from published literature and machine learning was built up with E model, among which the efficacy indicator was proteinuria change rates from baseline. 463 IMN patients were included for modeling, and tacrolimus therapeutic window concentrations were 4-10 ng/ml.
Results: In machine learning model, the E from tacrolimus effecting proteinuria in IMN patients was -72.7%, the ET was 0.43 months, and the time to achieving 25% E, 50% E, 75% E, and 80% (plateau) E of tacrolimus on proteinuria in patients with IMN were 0.15, 0.43, 1.29, and 1.72 months, respectively.
Conclusion: For achieving better therapeutic effects from tacrolimus on proteinuria in patients with IMN, tacrolimus concentration range need to be maintained at 4-10 ng/ml for at least 1.72 months.
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Source |
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| http://dx.doi.org/10.1007/s11255-024-04056-y | DOI Listing |
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