Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al. find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.
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| http://dx.doi.org/10.1016/j.molcel.2024.03.026 | DOI Listing |
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