Two new nervogenic acid derivatives liparisnervosides Q (1) and R (5), as well as five known nervogenic acid derivatives (2-4, 6, 7) and four phenanthrenes (8-11) were isolated from the whole plant of Liparis nervosa (Thunb. ex A. Murray) Lindl.. Their structures were detremined using extensive spectroscopic techniques, including 1D, 2D NMR, and HR-ESI-MS, and acid hydrolysis. Furthermore, their antimicrobial and immunosuppressive activities were evaluated. Nervosine VII (3) exhibited antimicrobial activity against Staphylococcus aureus with an MIC of 62.5 μg/mL and inhibited the proliferation of human T cells with an IC value of 9.67±0.96 μM. These findings contribute to our understanding of the potential pharmacological properties of these compounds.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/cbdv.202400721 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A mini review of species: an ornamental genus with considerable medicinal value.
Nat Prod Res
May 2024
Department of Pharmacy, Gannan Healthcare Vocational College, Ganzhou, China.
The genus , a group of perennial ornamental herbs in the family Orchidaceae, is widely distributed in tropical and subtropical regions. Many species of the genus have been commonly used as traditional herbal medicines for the treatment of menorrhagia, haemoptysis, traumatic bleeding, snake bites, and pneumonia. This review describes the ornamental value of plants of the genus and summarises the chemical constituents and pharmacological activities reported during the last decade.
View Article and Find Full Text PDFNervogenic Acid Derivatives and Phenanthrenes from Liparis nervosa and Their Antimicrobial and Immunosuppressive Activities.
Chem Biodivers
July 2024
College of Pharmacy, Key Laboratory of Research and Application of Ethnic Medicine Processing and Preparation on the Qinghai Tibet Plateau, Southwest Minzu University, Chengdu 6, 10041, China.
Two new nervogenic acid derivatives liparisnervosides Q (1) and R (5), as well as five known nervogenic acid derivatives (2-4, 6, 7) and four phenanthrenes (8-11) were isolated from the whole plant of Liparis nervosa (Thunb. ex A. Murray) Lindl.
View Article and Find Full Text PDFAntibacterial Prenylated -Hydroxybenzoic Acid Derivatives from and Identification of Putative Prenyltransferases.
J Nat Prod
February 2021
State Key Laboratory of Phytochemistry and Plant Resources in West China and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
Twelve hitherto unknown tandem prenylated -hydroxybenzoic acid derivatives, namely, oberoniamyosurusins A-L, together with five known derivatives, were isolated from an EtOH extract of the whole parts of the plant . Compounds , , and exhibited moderate inhibitory activity against subsp. ATCC29213 with MIC values ranging from 7.
View Article and Find Full Text PDFGenus Liparis: A review of its traditional uses in China, phytochemistry and pharmacology.
J Ethnopharmacol
April 2019
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China. Electronic address:
Ethnopharmacological Relevance: The plants of genus Liparis comprise approximately 428 species worldwide among these species 52 are widely distributed in China. These plants have long been used in China for the treatment of wound bleeding, detoxifying and inflammatory diseases, such as metrorrhagia, hemoptysis, traumatic hemorrhage, snakebite, and pneumonia.
Aim Of This Review: We intend to summarize traditional uses of Liparis spp.
A new nervogenic acid glycoside with pro-coagulant activity from Liparis nervosa.
Nat Prod Commun
August 2013
College of Biological Industry, Chengdu University, Chengdu 610106, PR China.
In an effort to identify hemostatic components from Liparis nervosa (Thunb.) Lindl. using a bioactivity-guided fractionation approach, the n-BuOH extract was found to promote ADP-induced platelet aggregation and two compounds were isolated from the active extract.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!