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Biases in Volumetric Versus Surface Analyses in Population Receptive Field Mapping.
Hum Brain Mapp
February 2025
BCBL - Basque Center on Cognition Brain and Language, Donostia - San Sebastián, Spain.
Population receptive field (pRF) mapping is a quantitative functional MRI (fMRI) analysis method that links visual field positions with specific locations in the visual cortex. A common preprocessing step in pRF analyses involves projecting volumetric fMRI data onto the cortical surface, typically leading to upsampling of the data. This process may introduce biases in the resulting pRF parameters.
View Article and Find Full Text PDFThe clinical breakpoint for a drug-pathogen combination reflects the drug susceptibility of the pathogen wild-type population, the location of the infection, the integrity of the host immune response, and the drug-pathogen pharmacokinetic (PK)/pharmacodynamic (PD) relationship. That PK/PD relationship, along with the population variability in drug exposure, is used to determine the probability of target attainment (PTA) of the PK/PD index at a specified minimum inhibitory concentration (MIC) for a selected target value. The PTA is used to identify the pharmacodynamic cutoff value (CO), which is one of the three components used to establish the clinical breakpoint.
View Article and Find Full Text PDFBayesian Spatial Relative Survival Model to Estimate the Loss in Life Expectancy and Crude Probability of Death for Cancer Patients.
Stat Med
February 2025
School of Mathematical Science, Queensland University of Technology, Brisbane, Australia.
To date, there have not been any population-based cancer studies quantifying geographical patterns of the loss in life expectancy (LLE) and crude probability of death due to cancer ( ). These absolute measures of survival are complementary to the more typically used relative measures of excess mortality and relative survival, and, together, they provide a fuller understanding of geographical disparities in survival outcomes for cancer patients. We propose using a spatially flexible parametric relative survival model in the Bayesian framework, which allows for the inclusion of spatial effects in hazard-level model components.
View Article and Find Full Text PDFSex-specific activation of platelet purinergic signaling is key in local cytokine release and phagocytosis in the peritoneal cavity in intra-abdominal sepsis.
Am J Physiol Cell Physiol
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, College of Health and Human Sciences, North Dakota State University, Fargo, ND, USA.
Intra-abdominal sepsis is a life-threatening complex syndrome caused by microbes in the gut microbiota invading the peritoneal cavity. It is one of the major complications of intra-abdominal surgery. To date, only supportive therapies are available.
View Article and Find Full Text PDFToward Equitable Access to Psychosocial Screening in Canada: Validation of the French-Canadian Psychosocial Assessment Tool.
Pediatr Blood Cancer
March 2025
Azrieli Research Centre, Centre Hospitalier Universitaire Sainte-Justine, Montréal, Québec, Canada.
Objective: The Psychosocial Assessment Tool (PAT) is a brief caregiver report, family-centered, psychosocial risk screening tool widely used in pediatrics and available in many languages. Although French is an official language of Canada, a French-Canadian version of the PAT has not yet been validated, which impedes access to this tool for family psychosocial screening. This study aimed to translate, adapt as necessary, and validate the French-Canadian version of the PAT.
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