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Genetic architecture of white striping in turkeys (Meleagris gallopavo). | LitMetric

AI Article Synopsis

  • White striping (WS) is a growing issue in the turkey industry that negatively impacts consumer acceptance and meat quality.
  • A genome-wide association study (GWAS) analyzed the severity of WS using data from over 8,400 turkey breast fillets and identified 95 candidate genes linked to the condition.
  • The study found that multiple genetic factors contribute to WS, highlighting significant biological pathways related to muscle growth, collagen formation, and response to stress, which may inform future research on the condition.

Article Abstract

White striping (WS) is a myopathy of growing concern to the turkey industry. It is rising in prevalence and has negative consequences for consumer acceptance and the functional properties of turkey meat. The objective of this study was to conduct a genome-wide association study (GWAS) and functional analysis on WS severity. Phenotypic data consisted of white striping scored on turkey breast fillets (N = 8422) by trained observers on a 0-3 scale (none to severe). Of the phenotyped birds, 4667 genotypic records were available using a proprietary 65 K single nucleotide polymorphism (SNP) chip. The SNP effects were estimated using a linear mixed model with a 30-SNP sliding window approach used to express the percentage genetic variance explained. Positional candidate genes were those located within 50 kb of the top 1% of SNP windows explaining the most genetic variance. Of the 95 positional candidate genes, seven were further classified as functional candidate genes because of their association with both a significant gene ontology and molecular function term. The results of the GWAS emphasize the polygenic nature of the trait with no specific genomic region contributing a large portion to the overall genetic variance. Significant pathways relating to growth, muscle development, collagen formation, circulatory system development, cell response to stimulus, and cytokine production were identified. These results help to support published biological associations between WS and hypoxia and oxidative stress and provide information that may be useful for future-omics studies in understanding the biological associations with WS development in turkeys.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11026500PMC
http://dx.doi.org/10.1038/s41598-024-59309-8DOI Listing

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