AI Article Synopsis
- Eczema and contact dermatitis are common but can significantly impact quality of life; this study explores the effects of bee venom acupuncture (BVA) and herbal medicine (San Wu Huangqin decoction; SWH) as a combination treatment.
- Case studies of two patients (one female, one male) showed that a three-month treatment with BVA and SWH led to the healing of their hand eczema and contact dermatitis, with no recurrence after one and three years.
- Additionally, animal tests demonstrated that this combination therapy improved clinical symptoms and decreased inflammation related to eczema-like dermatitis in mice, suggesting it could be a viable alternative treatment for these conditions.
Article Abstract
Introduction: Eczema and contact dermatitis are relatively common, non-life-threatening disease, but can reduce the patient's quality-of-life when it becomes chronic. This study describes two cases of bee venom acupuncture (BVA) and herbal medicine (San Wu Huangqin decoction; SWH) co-treatment for hand eczema and contact dermatitis, then confirms the effect of the combination therapy in an in vivo model of eczema.
Case Presentation: A 56-year-old female (case 1) and a 33-year-old male (case 2) presented to the clinic with symptoms of itching and erythema (case 1), and scaliness (case 2) on both hands. Both were diagnosed with hand eczema and contact dermatitis based on examination of the erythema and scaliness. They were treated with BVA and SWH for three months. The lesions were healed and had not recurred after 1 and 3 years of follow-up. A mouse study was conducted by repeated application of 2,4-dinitrochlorobenzene (DNCB) to induce eczema-like contact dermatitis in Balb/c mice. In a DNCB-induced eczema-like contact dermatitis model, BVA and SWH co-administration synergistically improved clinical symptoms seen in eczema. Also, they improved histological changes of the skin, suppressed immune cell infiltration, and decreased inflammatory cytokines and immunoglobulin E in the serum.
Conclusion: This study suggests BVA and SWH could be an alternative treatment for eczema and contact dermatitis.
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| http://dx.doi.org/10.1016/j.explore.2024.03.002 | DOI Listing |
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