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Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy.
Front Cell Dev Biol
December 2024
Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China.
Tumor immunotherapy, modulating innate and adaptive immunity, has become an important therapeutic strategy. However, the tumor immune microenvironment's (TIME) complexity and heterogeneity challenge tumor immunotherapy. Hydrogel is a hydrophilic three-dimensional (3D) mesh structure with good biocompatibility and drug release control, which is widely used in drug delivery, agriculture, industry, etc.
View Article and Find Full Text PDFDisplacement and stress response of open-web girders under near field explosive loading.
Sci Rep
December 2024
Research Center of Space Structures, Guizhou University, Guiyang, 550025, China.
This study employed numerical simulation to investigate the dynamic response characteristics of open-web girders subjected to proximity blast loading and to compare these characteristics with those of solid-web girders. The research utilized the Coupled Eulerian-Lagrangian (CEL) method for simulation, effectively combining the advantages of both Eulerian and Lagrangian approaches. This method mitigated issues related to mesh distortion while accurately modeling the damage inflicted by blast loads on the structures.
View Article and Find Full Text PDFStretchable and Shape-Transformable Organohydrogel with Gallium Mesh Frame.
Gels
November 2024
Electro-Medical Equipment Research Division, Korea Electrotechnology Research Institute (KERI), Ansan 15588, Republic of Korea.
Shape-memory materials are widely utilized in biomedical devices and tissue engineering, particularly for their ability to undergo predefined shape changes in response to external stimuli. In this study, a shape-transformable organohydrogel was developed by incorporating a gallium mesh into a polyacrylamide/alginate/glycerol matrix. The gallium mesh, which transitions between solid and liquid states at moderate temperatures (~29.
View Article and Find Full Text PDFImmune Checkpoint Inhibitors in Patients with Testicular Cancer: A Systematic Review.
J Adolesc Young Adult Oncol
December 2024
Facultad de Medicina, Centro de Desarrollo de Investigación 360, Universidad Autónoma de Nuevo León, Monterrey, Mexico.
Germ cell tumors (GCTs) are chemosensitive neoplasms with high cure rates; however, a small group of patients present tumors with refractory chemotherapy, with a dismal prognosis and few effective management options. Although immune checkpoint inhibitors (ICIs) are approved for use in chemotherapy refractory GCT, the evidence supporting this indication remains scarce. Original research studies were included on patients with GCTs refractory to chemotherapy treated with ICI up to December 2023.
View Article and Find Full Text PDFA model of co-creation: strengthening primary health care (PHC) in Ghana through an innovative "Nyansapo" partnership.
Front Med (Lausanne)
December 2024
School of Medicine, University College Dublin, Dublin, Ireland.
The Africa Health Collaborative (AHC) initiative embarked on a transformative ten-year collaboration with Kwame Nkrumah University of Science and Technology (KNUST) and the University of Toronto (U of T) to co-create continuing education programs geared toward augmenting the proficiency of primary care practitioners in Ghana. While upholding core principles within the AHC framework, emphasizing respect, inclusivity, equity, reciprocity, ethics, dynamism, and stewardship, seven teams of U of T and KNUST faculty engaged in collaborative efforts to design, administer, and evaluate five in-person "short courses" in Ghana on Palliative Care, Quality Improvement for Health Professionals, Prehospital Emergency Care, Community Emergency Care, and Emergency Preparedness and Response to Epidemic-Prone Diseases to approximately 100 Ghanaian primary care professionals. This paper describes a model of co-creation, highlights lessons learned from a robust evaluation process, and proposes that this co-creation model can strengthen primary health care in Ghana and ultimately transform health systems in Africa.
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