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http://dx.doi.org/10.1016/j.gassur.2024.04.015 | DOI Listing |
Biomolecules
December 2024
Department of Pharmacy, Division of Pharmacognosy and Natural Products Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
24-Masticadienonic acid (MNA) and 24-isomasticadienonic acid (IMNA) are the major triterpenic acids in Chios Mastic Gum (CMG), a resin derived from var. . Despite their promising pharmacological potential, limited information is available due to the complexity of isolating them in pure form.
View Article and Find Full Text PDFChemosphere
November 2024
Instituto Antártico Argentino (IAA/DNA), 25 de Mayo N° 1143, San Martín (1650), Buenos Aires, Argentina.
Plastic pollution has emerged as a growing environmental concern, affecting even the most remote regions of the planet as the Antarctic continent, endangering its ecosystem and contributing to climate change. In this context, a continuous atmospheric microplastics monitoring study was conducted at Carlini Argentine Antarctic Station located in the southwest of 25 de Mayo (King George) Island (South Shetlands). Passive samplers were installed at three locations throughout the station, chosen based on the intensity of human activity and proved to be effective in collecting atmospheric particles over a one-year study period.
View Article and Find Full Text PDFChem Biol Drug Des
November 2024
Programa de Pós-Graduação Em Química, Universidade Federal Do Espírito Santo, Vitória, ES, Brazil.
Comb Chem High Throughput Screen
October 2024
HTS Core Facility - Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
Introduction: Omacetaxine, a semisynthetic form of Homoharringtonine (HHT), was approved for the treatment of Chronic Myeloid Leukemia (CML). Previously, we have published the synthesis of this natural alkaloid and three of its derivatives: Deoxyharringtonine (DHT), Deoxyhomoharringtonine (DHHT), and Bis(demethyl)-deoxyharringtonine (BDHT), and reported its refractory activity against the HL-60/RV+ cells over-expressing P-glycoprotein 1 (MDR1).
Methods: In this study, we have explored the extent of this resistance by first expanding the panel of established cell lines and using a panel of 21 leukemia patient-derived primary cells.
Crit Rev Biotechnol
October 2024
NUS Centre for Cancer Research, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Statins are the most prescribed drug for regulating the high cholesterol level in the blood, which can lead to severe complications, such as cardiovascular diseases and other health complications. A wide range of analytical techniques have been employed for the quantification of statins from various origins, including fermentation derived (lovastatin, pravastatin, and compactin), semi-synthetic (simvastatin), and synthetic (atorvastatin, rosuvastatin, and fluvastatin) routes. The presence of more than one structural form and structural analogue generated in the biosynthesis pathway, as well as reaction intermediates and macromolecules in the clinical sample, complicates the quantification of statins.
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