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CAF-EVs carry lncRNA MAPKAPK5-AS1 into hepatocellular carcinoma cells and promote malignant cell proliferation.
Commun Biol
December 2024
The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Article Synopsis
- Hepatocellular carcinoma (HCC) is a serious cancer with a high risk of poor outcomes, and the lncRNA MAPKAPK5-AS1 is identified as an oncogene that aids in HCC cell growth.
- CAF-EVs (carcinoma-associated fibroblast-derived extracellular vesicles) deliver MAPKAPK5-AS1 to HCC cells, which inhibits SMURF2 and stabilizes TCF12, ultimately promoting HCC cell proliferation by upregulating FOXH1 expression.
- The study highlights potential new therapeutic targets for HCC treatment by demonstrating the role of CAF-EVs and MAPKAPK5-AS1 in tumor growth dynamics.
β-Asarone Inhibits Carboplatin Resistance in Retinoblastoma Cells Through the UCA1/miR-206/NRP1 Axis.
Biochem Genet
December 2024
Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated People's Hospital of Northwest University, No. 21 Jiefang Rd, Xi'an, 710004, Shaanxi, China.
Retinoblastoma (RB) is an aggressive form of eye cancer. β-Asarone is a bioactive component isolated from the medicinal plant Acorus tatarinowii Schott and has anticancer effects on various human cancers. However, reports regarding the role of β-Asarone in RB remain limited.
View Article and Find Full Text PDFElucidating Sex-Specific Immune Profiles in a Breast Cancer Model.
Int J Mol Sci
December 2024
Program in Cancer Biology, Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Breast cancer is commonly thought of as a "women's disease". However, men are increasingly diagnosed with the disease, and their mortality rates are disparately higher than those of female patients. The abundance and composition of the immune microenvironment are determinants of breast cancer progression and survival.
View Article and Find Full Text PDFCarcinoma-Associated Fibroblasts Accelerate Growth and Invasiveness of Breast Cancer Cells in 3D Long-Term Breast Cancer Models.
Cancers (Basel)
November 2024
Department of Pharmacology, Wayne State University, Detroit, MI 48201, USA.
Article Synopsis
- Carcinoma-associated fibroblasts (CAFs) play a crucial role in fostering cancer progression by interacting with cancer cells within the tumor microenvironment, highlighting the potential for targeting CAF-driven pathways as a new cancer treatment strategy.
- A novel three-dimensional (3D) coculture model was developed to study the long-term interactions of triple-negative breast cancer (TNBC) cells and CAFs, which revealed important insights into their paracrine signaling over at least 70 days.
- The study demonstrated that TNBC spheroids in 3D coculture with CAFs showed increased invasiveness compared to those with normal fibroblasts, alongside preferential migration patterns, suggesting CAFs significantly enhance TNBC aggressive behaviors.
Nasopharyngeal carcinoma-associated inflammatory cytokines: ongoing biomarkers.
Front Immunol
November 2024
TCM&VIP Inpatient Department, Sun Yat-sen University Cancer Center, Guangzhou, China.
Nasopharyngeal carcinoma (NPC) is a neoplasm related to inflammation; the expression of cytokines, such as CCL3, CCL4, CCL20, IL-1α, IL-1β, IL-6, IL-8, and IL-10, among others, is presumed to be associated with NPC occurrence and development. Therefore, the circulating levels of these cytokines may be potential biomarkers for assessing tumor aggressiveness, exploring cellular interactions, and monitoring tumor therapeutic responses. Numerous scholars have comprehensively explored the putative mechanisms through which these inflammatory factors affect NPC progression and therapeutic responses.
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