AI Article Synopsis
- Rift Valley fever virus (RVFV) is a mosquito-borne illness found in Africa and the Middle East, known to cause serious brain infections (encephalitis) that can result in high rates of illness and death.
- Recent research has developed new mouse models that help understand how RVFV causes encephalitis, emphasizing the importance of viral strain and method of infection in studying the virus.
- The review highlights the need to further investigate how genetic factors and immune responses of hosts affect RVFV disease and suggests potential approaches for preventing and treating the neurological effects of the virus, while acknowledging areas that still require research.
Article Abstract
Rift Valley fever virus (RVFV) is a mosquito-borne virus endemic to Africa and the Middle East. RVFV infection can cause encephalitis, which is associated with significant morbidity and mortality. Studies of RVFV encephalitis following percutaneous inoculation, as would occur following a mosquito bite, have historically been limited by a lack of consistent animal models. In this review, we describe new insights into the pathogenesis of RVFV and the opportunities provided by new mouse models. We underscore the need to consider viral strain and route of inoculation when interpreting data obtained using animal models. We discuss the trafficking of RVFV and the role of host genetics and immunity in modulating the pathogenesis of RVFV encephalitis. We also explore potential strategies to prevent and treat central nervous system disease caused by RVFV and discuss remaining knowledge gaps.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11427164 | PMC |
| http://dx.doi.org/10.1146/annurev-virology-093022-011544 | DOI Listing |
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