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Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner. | LitMetric
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Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.

Aikaterini Karagianni Anastasia Iris Karkempetzaki Daniel Brooks Shinobu Matsuura Vrinda Dambal Philip C Trackman Katya Ravid

Blood

Department of Medicine, Whitaker Cardiovascular Research Institute, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.

Published: June 2024

Lysyl oxidase (LOX) is a facilitator of extracellular matrix cross-linking. Using newly developed megakaryocyte-specific LOX knockout mice, we show that LOX expressed in these scarce bone marrow cells affects bone volume and collagen architecture in a sex-dependent manner.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196861PMC
http://dx.doi.org/10.1182/blood.2024024620DOI Listing

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