Potassium affects the association between dietary intake of vitamin C and NAFLD among adults in the United States.

PLoS One

Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Published: April 2024

AI Article Synopsis

  • The study investigates how dietary potassium intake influences the relationship between vitamin C and nonalcoholic fatty liver disease (NAFLD).
  • A large sample of 9,443 participants was analyzed using NHANES data from 2007-2018, examining the negative association between vitamin C and both NAFLD and advanced hepatic fibrosis (AHF).
  • Results indicated that potassium intake modifies this relationship, suggesting that combining potassium with vitamin C could be beneficial in managing NAFLD, highlighting its potential clinical significance.

Article Abstract

Introduction: Although the association between nonalcoholic fatty liver disease (NAFLD) and vitamin C has been well studied, the effects of dietary potassium intake on this relationship are still unclear. Thus, this study aimed to determine the effects of dietary potassium intake on the association between vitamin C and NAFLD.

Methods: We performed a cross-sectional learn about with 9443 contributors the usage of 2007-2018 NHANES data. Multiple logistic regression evaluation has been utilized to check out the affiliation of dietary vitamin C intake with NAFLD and advanced hepatic fibrosis (AHF). Subsequently, we plotted a smoothed match curve to visualize the association. Especially, the analysis of AHF was conducted among the NAFLD population. In addition, stratified evaluation used to be developed primarily based on demographic variables to verify the steadiness of the results. Effect amendment by way of dietary potassium intake used to be assessed via interplay checks between vitamin C and NAFLD in the multivariable linear regression.

Results: In this cross-sectional study, we found that vitamin C was negatively related to NAFLD and AHF. The relationship between vitamin C and NAFLD was different in the low, middle and high potassium intake groups. Furthermore, potassium intake significantly modified the negative relationship between vitamin C and NAFLD in most of the models.

Conclusion: Our research showed that potassium and vitamin C have an interactive effect in reducing NAFLD, which may have great importance for clinical medication.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11025862PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0295986PLOS

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