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Altered Atlas of Exercise-Responsive MicroRNAs Revealing miR-29a-3p Attacks Armored and Cold Tumors and Boosts Anti-B7-H3 Therapy.
Research (Wash D C)
January 2025
Department of Sports Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
Increasing evidence has shown that physical exercise remarkably inhibits oncogenesis and progression of numerous cancers and exercise-responsive microRNAs (miRNAs) exert a marked role in exercise-mediated tumor suppression. In this research, expression and prognostic values of exercise-responsive miRNAs were examined in breast cancer (BRCA) and further pan-cancer types. In addition, multiple independent public and in-house cohorts, in vitro assays involving multiple, macrophages, fibroblasts, and tumor cells, and in vivo models were utilized to uncover the tumor-suppressive roles of miR-29a-3p in cancers.
View Article and Find Full Text PDFCuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications.
J Transl Med
January 2025
Department of Pathophysiology, Zunyi Medical University, Zunyi, Guizhou, 563000, China.
Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms and signaling pathways. In this review, we delve into the cellular metabolic pathways of copper, highlighting the role of copper in biomolecule synthesis, mitochondrial respiration, and antioxidant defense. Furthermore, we elucidate the relationship between cuproptosis-related genes (CRGs) and cancer prognosis, analyzing their expression patterns across various tumor types and their impact on patient outcomes.
View Article and Find Full Text PDFSmall molecules and heat treatments reverse vernalization via epigenetic modification in Arabidopsis.
Commun Biol
January 2025
Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology (NAIST), Ikoma, Japan.
Monocarpic plants flower only once and then produce seeds. Many monocarpic plants require a cold treatment known as vernalization before they flower. This requirement delays flowering until the plant senses warm temperatures in the spring.
View Article and Find Full Text PDFNurses' Attitudes Toward Holistic and Complementary Medicine in Pain Management.
Pain Manag Nurs
January 2025
Aksehir KadirYallagoz Health School, Selcuk University, Aksehir, Konya, Turkiye.
Background: The effects of nurses' attitudes toward complementary and alternative medicine (CAM) in pain management in terms of safety and quality of life are important. Nurses turn to a CAM approach to deal with pain problems.
Aim: This study aimed to investigate nurses' attitudes toward CAM and to determine their sociodemographic and pain-related characteristics.
A powerful organic photosensitizer for effective treatment of malignant tumor via activating antitumor immune response.
Chembiochem
January 2025
Peking University Cancer Hospital: Beijing Cancer Hospital (inner mongolia campus), Department of Interventional Therapy, CHINA.
Photodynamic therapy (PDT) has emerged as an innovative approach in cancer treatment, effectively inducing tumor cell death through light-triggered reactive oxygen species (ROS) generation. Additionally, PDT can also trigger antitumor immune responses, thereby reducing the risk of postoperative tumor recurrence. However, the development of highly efficient photosensitizers aimed at activating immune responses for comprehensive tumor eradication remains at an early stage.
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