AI Article Synopsis
- A new method for using light to convert α-fluoroacrylic acids into difluoroalkylated and polyfluoroalkylated compounds has been developed.
- This approach is versatile, allowing the use of various starting materials and producing specific monofluoroalkenes with a desirable structure under mild conditions.
- The technique works well with different functional groups, making it useful for modifying complex biological molecules.
Article Abstract
Herein, a novel and practical methodology for the photoinduced decarboxylative difluoroalkylation and perfluoroalkylation of α-fluoroacrylic acids is reported. A wide range of α-fluoroacrylic acids can be used as applicable feedstocks, allowing for rapid access to structurally important difluoroalkylated and polyfluoroalkylated monofluoroalkenes with high Z-stereoselectivity under mild conditions. The protocol demonstrates excellent functional group compatibility and provides a platform for modifying complex biologically active molecules.
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| http://dx.doi.org/10.1021/acs.joc.4c00684 | DOI Listing |
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