Background Objectives: At present, use of synthetic pesticides to manage insects and other arthropods creates a number of issues that are related to the environment and public health. The goal of the present study is to find repellent activity of Vitex negundo and Curcuma longa herbal extracts against the wild species Simulium (blackfly) bite.
Methods: We have studied Simulium biting behavior and tested the repellency of herbal extract obtained from Vitex negundo L. (Lamiales: Lamiaceae) and Curcuma longa L. (Zingiberal: Zingiberaceae) along with their essential oils in three locations in Arunachal Pradesh, India on human volunteers' resistance to Simulium (blackflies). The reported herbal extracts were incorporated to topical drug delivery vehicle as a cream and gel.
Results: The methanolic extract of Vitex negundo cream and gel formulation showed >2 h safety at 5% concentration and >5 h safety at 10% concentration in all the testing sites followed by ethyl acetate extract. Whereas, chloroform extract of Curcuma longa cream and gel formulation provided >1 h safety at 5% concentration and >4 h safety at 10% concentration.
Interpretation Conclusion: At an optimum concentration of 10%, the methanolic extract of Vitex negundo cream provided complete protection times (CPTs) 320.4, 358.6, and 346.4 min, respectively. These findings offer confirmation of the methanolic extract and chloroform extract potential for use in new blackfly repellents.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.4103/JVBD.JVBD_181_23 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
identification of Nipah virus protein inhibitors from secondary metabolites of medicinal plants using a high-throughput virtual screening approach.
J Biomol Struct Dyn
December 2024
Department of Science and Technology, Virology and Vaccine Research Program, Industrial Technology Development Institute, Taguig City, Philippines.
The Nipah virus (NiV), a highly pathogenic zoonotic virus of the family, poses significant threats with its alarming mortality rates and pandemic potential. Despite historical cases, effective therapeutics remain elusive, prompting urgent exploration of potential antivirals. In this study, a structure-based virtual screening approach was employed to evaluate 690 metabolites sourced from ten medicinal plants () for their antiviral activity against Nipah virus proteins.
View Article and Find Full Text PDFCombination of methanolic-extract with cisplatin can induce antioxidant activity and apoptosis in HeLa and Caski cells.
Front Pharmacol
December 2024
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Background: Cisplatin-based chemotherapy as a common therapeutic regimen for cervical cancer patients, is becoming more and more ineffective due to high resistance. This urges the need for introducing novel metabolics such as botanical drugs with the capacity to increase the cisplatin effectiveness. In that regard, here we investigated the anticancer effects of the Cisplatin- combination in cervical cancer cell lines.
View Article and Find Full Text PDFSelective protease inhibitors from secondary metabolites of Philippine medicinal plants against porcine epidemic diarrhea virus: A computational veterinary drug discovery approach.
Open Vet J
September 2024
Virology and Vaccine Research and Development Program, Department of Science and Technology, Industrial Technology Development Institute, Taguig, Philippines.
Background: Porcine epidemic diarrhea virus (PEDV) is a recurring coronavirus that causes severe diarrhea in pigs with high mortality and morbidity rates, especially in neonatal pigs. Despite the availability of vaccines, their efficacy is limited owing to antigenic differences between the vaccine and field strains, which poses a challenge to infection control. Antiviral drugs targeting conserved PEDV proteins show promise for complementing vaccination strategies.
View Article and Find Full Text PDFBioactive Phytophenolics of Vitex negundo Reveal Therapeutic Antifungal Potentials against Candida albicans.
Chin J Integr Med
November 2024
Department of Biotechnology, National Institute of Technology, Raipur, CG, 492010, India.
Objective: To map the potent antifungal properties of the medicinal plant Vitex negundo, in vitro and in silico studies were performed to decipher the pharmacokinetics and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties of their phytoconstituents.
Methods: With the PASS (Prediction of Activity Spectra for Substances) prediction tool, many parameters of V. negundo phenolics were examined, including drug-likeness, bioavailability, antifungal activity, and anti-biofilm activity.
Anti-proliferative Activity of Leaf Extracts on PA1 Human Ovarian Cancer Cell Lines.
Arch Razi Inst
April 2024
Basic Science Research Centre, KLE Academy of Higher Education and Research (KLE University), Belagavi, Karnataka, India.
In Ayurveda, (VN) is used as a drug to manage pain, inflammation, and problems related to polycystic ovary disease and the menstrual cycle. The bioactive compounds isolated from this plant exhibit anti-inflammatory, anti-oxidant, anti-cancer, and microbicidal properties. The shrub VN is known for its role in the modulation of cellular events like apoptosis and cell cycle.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!