AI Article Synopsis
- The study investigates the link between bone turnover markers (BTM) and vitamin D receptor gene polymorphisms with bone mineral density (BMD) in patients with Type 1 and Type 2 diabetes mellitus (DM).
- It involved 165 patients, assessing their BMD and levels of specific bone markers, revealing higher osteocalcin (OC) and propeptide levels in Type 1 DM compared to Type 2, but no significant differences in BMD between the two groups.
- The findings suggest that certain gene polymorphisms are associated with lower lumbar BMD and higher OC levels, indicating that OC could be a valuable predictor for bone loss risk in diabetic patients, potentially guiding personalized treatment strategies.
Article Abstract
Objectives: Bone metabolism is impaired in diabetes mellitus (DM). Our objective is to evaluate the association of bone turnover markers (BTM) and vitamin D receptor () gene polymorphisms with bone mineral density (BMD) in DM type 1 (T1D) and DM type 2 (T2D).
Methods: A total of 165 patients (53 T1D and 112 T2D) were enrolled. BMD was measured by dual-energy X-ray absorptiometry (DEXA). Plasma osteocalcin (OC), beta-CrossLaps (β-CTX) and N-amino terminal propeptide of type I collagen (P1NP) and gene polymorphisms were evaluated.
Results: Participants were 53 T1D (41 years [31-48]) and 112 T2D (60 years [51-66]). BMD were not statistically different between the groups. OC (p<0.001) and P1NP levels (p<0.001) were higher in patients with T1D. The areas under the curve for the prediction of bone pathology were 0.732 (p=0.038) for OC in T1D and 0.697 (p=0.007) in T2D. A significant association was found between lower lumbar BMD and the A allele of (p=0.03), the A allele of (p=0.04) and the allele C of the (p=0.046). Also, a significant correlation was found with higher OC levels and the G allele of (p=0.044), C allele of (p=0.011), T allele of (p=0.006) and with C allele of (p=0.004).
Conclusions: The high negative predictive value of the cut-off point for OC suggests that could be useful in excluding the risk suffering bone loss, allowing offering a personalized clinical approach to prevent this pathology.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11019880 | PMC |
| http://dx.doi.org/10.1515/almed-2023-0131 | DOI Listing |
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