Objective: We aimed to define the clinical features and antimicrobial susceptibility profiles of complex infections and to determine the predictors for mortality.
Materials And Methods: Our single-center retrospective study included patients with nosocomial complex infection between 2018 and 2022. We evaluated the predictors of 14-day and 28-day mortality by analyzing clinical and microbiological data.
Results: A total of 87 patients were included. Most infections (79.3%) occurred in the intensive care units (ICUs). Among complex isolates, 74.7% were susceptible to trimethoprim-sulfamethoxazole, 70.3% to levofloxacin, 50% to meropenem, and 23.4% to ceftazidime. The rates of 14-day mortality, 28-day mortality, and in-hospital mortality were 41.3% (n=36), 52.8% (n=46), and 64.3% (n=56), respectively. Multivariate analysis revealed neutrophil/lymphocyte ratio (NLR) (odds ratio [OR]=1.05, =0.024), platelet count (OR=1.00, =0.011), creatinine (OR=2.14, =0.006), and aspartate aminotransferase (AST) (OR=1.02, =0.028) as predictors for 14-day mortality. In addition to NLR (OR=1.07, =0.014), platelet count (OR=1.00, =0.039), creatinine (OR=2.05, =0.008), and AST (OR=1.02, =0.035), procalcitonin (OR=1.05, =0.049) was also found as an independent predictor for 28-day mortality. In receiver operating characteristic (ROC) curve analysis for predicting 14-day mortality, area under the ROC curve (AUC) values were 0.684 (=0.003) in NLR, 0.719 (<0.001) in platelet count, 0.673 (=0.003) in procalcitonin, 0.743 (<0.001) in creatinine, and 0.700 (<0.001) in AST. In ROC curve analysis for predicting 28-day mortality, AUC values were 0.674 (=0.002) in NLR, 0.651 (=0.010) in platelet count, 0.638 (=0.020) in procalcitonin, 0.730 (<0.001) in creatinine, and 0.692 (=0.001) in AST.
Conclusion: Increasing antibiotic resistance and higher mortality rates justify that complex is a significant threat to hospitalized patients, especially in ICUs. Elevated levels of NLR, AST, creatinine, procalcitonin, and decreased platelet may predict poor clinical outcomes and could help clinicians in the management of this notorious bacterial pathogen.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985821 | PMC |
| http://dx.doi.org/10.36519/idcm.2023.259 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Association between stress hyperglycemia ratio and mortality in patients with heart failure complicated by sepsis.
Sci Rep
December 2024
The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Nanjing, China, 214000.
Individuals afflicted with heart failure complicated by sepsis often experience a surge in blood glucose levels, a phenomenon known as stress hyperglycemia. However, the correlation between this condition and overall mortality remains unclear. 869 individuals with heart failure complicated by sepsis were identified from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and categorized into five cohorts based on their stress hyperglycemia ratio (SHR).
View Article and Find Full Text PDFMortality rates and risk factors associated with mortality in patients with stenotrophomonas maltophilia primary Bacteraemia and Pneumonia.
Diagn Microbiol Infect Dis
December 2024
Department of Infectious Diseases and Clinical Microbiology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
This study aims to evaluate the risk factors associated with the mortality of S. maltophilia infections. Patients aged 18 years and older with S.
View Article and Find Full Text PDFReal-world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury.
Ann Clin Transl Neurol
December 2024
Department of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Objective: The short-term efficacy of red blood cell (RBC) transfusion among general traumatic brain injury (TBI) patients is unclear.
Methods: We used the MIMIC database to compare the efficacy of liberal (10 g/dL) versus conservative (7 g/dL) transfusion strategy in TBI patients. The outcomes were neurological progression (decrease of Glasgow coma scale (GCS) of at least 2 points) and death within 28 days of ICU admission.
Association between body temperature and all-cause mortality in patients with sepsis: analysis of the MIMIC-IV database.
Eur J Med Res
December 2024
Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Abnormal body temperature (fever or hypothermia) is a critical symptom in sepsis and is strongly associated with clinical prognosis and disease progression. Given the duality and variability of body temperature fluctuations throughout the disease course, further research is essential to refine clinical strategies for temperature management in sepsis patients.
Methods: We extracted clinical data of sepsis patients from the MIMIC-IV database.
Efficacy and safety of Chinese tonic medicines for treating sepsis or septic shock: a protocol for a systematic review and Bayesian network meta-analysis of randomized controlled trials.
Syst Rev
December 2024
West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Background: Sepsis is a life-threatening organ dysfunction with high morbidity and mortality. Various studies have demonstrated the effectiveness of Chinese tonic medicines (CTMs) in treating sepsis or septic shock. However, trials directly comparing the efficacy and safety of different CTMs for sepsis or septic shock are still lacking.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!