What Is Already Known On This Topic?: Exposure to fine particulate matter (PM) was linked to endocrine hormone disruption in the reproductive system. Nonetheless, it was unclear which specific components of PM were primarily responsible for these associations.
What Is Added By This Report?: The study presented the initial epidemiological evidence that brief exposure to PM can elevate estradiol levels in postmenopausal women. Various particle components had unique effects, with water-soluble ions and specific inorganic elements like Ag, As, Cd, Hg, Ni, Sb, Se, Sn, and Tl potentially playing significant roles in increasing estradiol levels.
What Are The Implications For Public Health Practice?: The study established that the prevalence of air pollution, along with its specific components, has been recognized as a novel risk factor affecting the balance of sex hormones.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11018549 | PMC |
http://dx.doi.org/10.46234/ccdcw2024.049 | DOI Listing |
Alzheimers Dement
December 2024
Univeristy of Washington School of Public Health, Seattle, WA, USA.
Background: Long-term exposure to ambient air pollution-including fine particulate matter <2.5µm in diameter (PM)-has previously been associated with incident dementia. As climate change drives longer and more intense wildfire seasons, exposure to PM produced by wildfires may be a unique and increasingly important risk factor for dementia.
View Article and Find Full Text PDFBackground: The goal of this study was to determine the incidence of dementia before age 65 years in a prospective study of WTC responders, and compare incidence among responders with severe exposures to debris versus responders not exposed to building debris or those who wore personalized protective equipment (PPE).
Methods: Data were collected in a congressionally mandated academic occupation-based medical monitoring program available to all verified WTC-exposed responders residing on Long Island, NY, most of whom are currently <65 years of age. WTC responders aged ≤60 years without dementia at the time of their first cognitive assessment were followed every 18 months on average, for up to five years.
Alzheimers Dement
December 2024
Bordeaux Population Health Research Center, Inserm U1219, University of Bordeaux, Bordeaux, France.
This critical overview aims to provide one of the most comprehensive synthesis of epidemiological and experimental evidence relating the chemical exposome to Alzheimer's Disease (AD). We have focused on chemical pollutants that mostly result from anthropic activities and involved in toxicology pathways, including pesticides, organic solvents, metals, combustion air pollutants, dioxins, flame retardants, fluorosurfactants, plastic components and food/cosmetic additives. In total, we have reviewed over 120 epidemiological studies examining the link between chemical exposures and the risk of AD or cognitive impairment in older adults, along with more than 250 experimental studies assessing the impact of chemical exposures on neurodegeneration-related pathways.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Umeå Center for Functional Brain Imaging, Umeå University, Umeå, Sweden.
Background: Long-term exposure to ambient air pollution has recently been highlighted as a modifiable risk factor for dementia. However, the mechanisms underlying these associations still remain unclear. The goal of this study was to investigate the associations between air pollution and neuroimaging correlates in a sample of middle-aged and older adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Amgen Biotechnology Research, Thousand Oaks, CA, USA.
Background: Late-life exposure to PM is a risk factor for Alzheimer's disease (AD) and related dementias. Accelerated brain aging associated with PM exposure likely takes place at preclinical stage. In Feb.
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