AI Article Synopsis
- Ephedra plants, known for their ephedrine alkaloids, are traditionally used in Eastern Asian medicine.
- This study focused on isolating non-ephedrine compounds from different Ephedra species grown in Japan.
- HPLC analysis revealed significant amounts of kynurenic acid and its derivatives, along with a large quantity of (2R,3S)-O-benzoyl isocitrate from E. intermedia, highlighting the diversity of non-ephedrine constituents in Ephedra plants.
Article Abstract
Ephedra plants, the main components of which are ephedrine alkaloids, are used as traditional medicines in Eastern Asian countries. In this study, we isolated non-ephedrine constituents from various Ephedra plant species cultivated in Japan. HPLC analysis suggested that kynurenic acid and its derivatives accumulated in a wide range of Ephedra plant species. Furthermore, a large amount of (2R,3S)-O-benzoyl isocitrate has been isolated from E. intermedia. This study suggests that Ephedra plants have diverse non-ephedrine constituents.
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| http://dx.doi.org/10.1248/cpb.c24-00043 | DOI Listing |
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Comparison of Non-ephedrine Constituents from Ephedra Plants Cultivated in Japan.
Chem Pharm Bull (Tokyo)
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College of Pharmaceutical Sciences, Ritsumeikan University.
Article Synopsis
- Ephedra plants, known for their ephedrine alkaloids, are traditionally used in Eastern Asian medicine.
- This study focused on isolating non-ephedrine compounds from different Ephedra species grown in Japan.
- HPLC analysis revealed significant amounts of kynurenic acid and its derivatives, along with a large quantity of (2R,3S)-O-benzoyl isocitrate from E. intermedia, highlighting the diversity of non-ephedrine constituents in Ephedra plants.
Non-ephedrine constituents from the herbaceous stems of Ephedra sinica.
Fitoterapia
September 2021
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xueyuan Road, Haidian District, Beijing 100191, China. Electronic address:
Three new flavonoids, ephedroside A (1), ephedroside B (2), ephedroside C (3), together with fifty-four known compounds 4-57 were isolated from the EtOH extract of the herbaceous stems of Ephedra sinica. The structures of these compounds were elucidated by spectroscopic techniques, as well as by comparison with literature data. Thirty-eight of these compounds were isolated from the genus Ephedra for the first time.
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