AI Article Synopsis
- Anoikis significantly affects lung adenocarcinoma (LUAD) by influencing patient prognosis and immune responses, but its exact role is not fully understood.
- The study identified two distinct patient clusters based on nine apoptotic factors, with one cluster showing higher levels of immune cell infiltration.
- Researchers also pinpointed two key genes, SLC2A1 and SPHK1, that impact tumor behavior and prognosis, suggesting the need for further research to enhance treatment strategies for LUAD.
Article Abstract
Anoikis plays a crucial role in the progression, prognosis, and immune response of lung adenocarcinoma (LUAD). However, its specific impact on LUAD remains unclear. In this study, we investigated the intricate interplay of nesting apoptotic factors in LUAD. By analyzing nine key nesting apoptotic factors, we categorized LUAD patients into two distinct clusters. Further examination of immune cell profiles revealed that Cluster A exhibited greater infiltration of innate immune cells than did Cluster B. Additionally, we identified two genes closely associated with prognosis and developed a predictive model to differentiate patients based on molecular clusters. Our findings suggest that the loss of specific anoikis-related genes could significantly influence the prognosis, tumor microenvironment, and clinical features of LUAD patients. Furthermore, we validated the expression and functional roles of two pivotal prognostic genes, solute carrier family 2 member 1 (SLC2A1) and sphingosine kinase 1 (SPHK1), in regulating tumor cell viability, migration, apoptosis, and anoikis. These results offer valuable insights for future mechanistic investigations. In conclusion, this study provides new avenues for advancing our understanding of LUAD, improving prognostic assessments, and developing more effective immunotherapy strategies.
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| http://dx.doi.org/10.1016/j.yexcr.2024.114037 | DOI Listing |
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