AI Article Synopsis
- Invasive infections caused by 89 strains, particularly from clade 3, are on the rise globally, including in Japan where specific features of these strains are largely unknown.
- This study analyzed 89 STSS isolates and 72 non-STSS isolates from Japan (2011-2019) using whole-genome sequencing, revealing that most belonged to clade 3, regardless of whether they caused severe disease.
- The research also identified critical factors associated with invasive disease in these strains, such as specific mutations and the absence of a gene for hyaluronidase, contributing to our understanding of their genetic characteristics.
Article Abstract
Invasive infection caused by 89 strains has been increasing in several countries linked to a recently emergent clade of 89 strains, designated clade 3. In Japan, the features of 89 strains, such as clade classification, remains unknown. In this study, we collected 89 strains isolated from both streptococcal toxic shock syndrome (STSS) (89 STSS isolates) and noninvasive infections (72 non-STSS isolates) in Japan from 2011 to 2019, and conducted whole-genome sequencing and comparative analysis, which resulted in classification of a large majority into clade 3 regardless of disease severity. In addition, invasive disease-associated factors were found among 89 strains, including mutations of control of virulence sensor, and absence of the gene encoding hyaluronidase. These findings provide new insights into genetic features of 89 strains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7769053 | PMC |
| http://dx.doi.org/10.1097/IM9.0000000000000038 | DOI Listing |
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