AI Article Synopsis
- Bunting total alkaloid (CSBTA) was tested for its antibacterial effects using various scientific methods like SEM, RT-qPCR, and ELISA.
- CSBTA treatment led to significant changes, such as the shrinkage and rupture of bacteria, reduced biofilm density, and lower expression of virulence-related mRNA genes.
- The findings suggest that CSBTA kills free bacteria, disrupts biofilm formation, and could potentially serve as a new drug for treating bacterial infections.
Article Abstract
To investigate the antibacterial effects of bunting total alkaloid (CSBTA) on . SEM, chemical staining, RT-qPCR and ELISA were used to detect effects of CSBTA on . CSBTA treatment caused shrinkage and rupture of morphology, decreased biofilm density and live bacteria in biofilm, as well as reduced mRNA expression of virulence genes , , , and of . Furthermore, NOK cells induced by CSBTA-treated exhibited lower IL-6 and TNF-α expression levels. CSBTA is able to kill free , disrupt the biofilm and weaken the pathogenicity of . It has the potential to be developed as a drug against infection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229583 | PMC |
| http://dx.doi.org/10.2217/fmb-2023-0165 | DOI Listing |
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