AI Article Synopsis
- Inflammatory myofibroblastic tumours (IMTs) in the gynaecological tract have gained recognition due to improved RNA-based molecular assays that detect ALK rearrangements, enhancing our understanding of these tumors.
- The review covers clinical features, morphological variations, immunohistochemical profiles, and the molecular basis of uterine IMTs, alongside diagnostic challenges, especially concerning similarities with smooth muscle tumors and issues during pregnancy.
- Recent studies indicate that uterine IMTs can exhibit aggressive behavior, leading to the development of a new risk stratification model to better identify high-risk cases.
Article Abstract
The current understanding of inflammatory myofibroblastic tumours (IMTs) of the gynaecological tract has recently been enhanced by their increased recognition. This increase is largely due to greater accessibility to RNA-based molecular assays used to identify their defining ALK rearrangements. This review summarises the clinical characteristics, morphological spectrum, immunohistochemical profile and molecular underpinnings of uterine IMT. Additionally, this review discusses practical diagnostic considerations including overlap between uterine IMT and smooth muscle tumours as well as pregnancy-associated uterine IMT. Finally, we highlight recent literature demonstrating the potential for aggressive behaviour in uterine IMT, including a novel risk stratification model for identifying high-risk IMT.
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| http://dx.doi.org/10.1111/his.15194 | DOI Listing |
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