In this paper, we consider the structural change in a class of discrete valued time series, where the true conditional distribution of the observations is assumed to be unknown. The conditional mean of the process depends on a parameter which may change over time. We provide sufficient conditions for the consistency and the asymptotic normality of the Poisson quasi-maximum likelihood estimator (QMLE) of the model. We consider an epidemic change-point detection and propose a test statistic based on the QMLE of the parameter. Under the null hypothesis of a constant parameter (no change), the test statistic converges to a distribution obtained from increments of a Browninan bridge. The test statistic diverges to infinity under the epidemic alternative, which establishes that the proposed procedure is consistent in power. The effectiveness of the proposed procedure is illustrated by simulated and real data examples.
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http://dx.doi.org/10.1080/02664763.2023.2179567 | DOI Listing |
Eur Stroke J
March 2025
Institute of Cardiovascular and Metabolic Sciences, University of Glasgow, Glasgow, UK.
Introduction: A better understanding of who will develop dementia can inform patient care. Although MRI offers prognostic insights, access is limited globally, whereas CT-imaging is readily available in acute stroke. We explored the prognostic utility of acute CT-imaging for predicting dementia.
View Article and Find Full Text PDFInfect Control Hosp Epidemiol
March 2025
Infectious Disease Clinical Research Program, Department of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Objective: Evaluate Department of Defense (DoD) antimicrobial stewardship programs (ASPs) by assessing the relationship between key clinical outcome metrics (antibiotic use, incidence of resistant pathogens, and incidence of infections) and CDC Core Element (CE) adherence.
Design: Retrospective, cross-sectional study of DoD hospitals in 2018 and 2021.
Methods: National Healthcare Safety Network Standardized Antimicrobial Administration Ratios (SAARs) were used to measure antibiotic use and microbiology results to evaluate four types of pathogen incidence.
Arterioscler Thromb Vasc Biol
March 2025
Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston (D.M.M., Z.Z.).
There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induced by chemical interventions, genetic manipulations, or both. Many parameters should be deliberated in experimental design in concert with multiple considerations when providing dimensional data and characterization of aortic tissues.
View Article and Find Full Text PDFFront Immunol
March 2025
Department of Pediatrics, Gynecology and Obstetrics, Faculty of Medicine, Geneva, Switzerland.
Background And Aims: Autoantibodies against apolipoprotein A-1 (AAA1) are elicited by SARS-CoV-2 infection and predict COVID-19 symptoms persistence at one year in adults, but whether this applies to children is unknown. We studied the association of SARS-CoV-2 exposure with AAA1 prevalence in children and the association of AAA1 seropositivity with symptom persistence.
Methods: Anti-SARS-CoV-2 and AAA1 serologies were examined in 1031 participants aged 6 months to 17 years old from the prospective SEROCOV-KIDS cohort and recruited between 12.
Health Sci Rep
March 2025
Department of Orthotics and Prosthetics, School of Rehabilitation Shahid Beheshti University of Medical Sciences Tehran Iran.
Background And Aims: The study aimed to determine the relationship between phubbing behavior and its association with depression, anxiety, and stress among college students of the School of Rehabilitation at Shahid Beheshti University of Medical Sciences.
Methods: This cross-sectional survey design used a self-reported questionnaire that included demographic data, DASS21, and a phubbing scale. The Generic Scale of Phubbing was administered to 320 students from four fields of school of Rehabilitation at Shahid Beheshti University of Medical Sciences.
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