AI Article Synopsis
- The study investigates the links between left ventricular (LV) function improvement (called LVRR) and the resolution of left ventricular thrombus (LVT) in patients.
- Conducted on patients diagnosed with LVT, the research compared outcomes between those who experienced LVRR and those who did not, finding that LVRR was associated with better outcomes.
- The findings emphasize the importance of addressing LV function issues to improve LVT resolution and reduce the risk of complications like embolic events.
Article Abstract
Aims: Recent years, several studies have suggested that abnormal baseline left ventricular (LV) function and structure are associated with left ventricular thrombus (LVT) formation. Despite this, most studies have given less attention to the potential role of left ventricular reverse remodelling (LVRR), that is, the improvement of LV function and structure, in resolving LVT. In this study, we aim to investigate the clinical characteristics, prognosis, and LVT resolution in patients with LVRR.
Methods And Results: This is a retrospective study conducted at The First Affiliated Hospital of Dalian Medical University. Our cohort consists of patients diagnosed with LVT between 1 November 2015 and 31 May 2020. Enrolled patients were categorized into two groups: LVRR and Failure of LVRR. The primary endpoints included LVT resolution and embolic events. A total of 84 patients were included in the study, with 59 patients in the LVRR group and 25 patients in the Failure of LVRR group. In our study, patients in the LVRR group experienced higher incidence of LVT resolution and a lower risk of embolic events. Multivariate logistic analysis revealed that Failure of LVRR was the only independent negative predictor for LVT resolution and positive predictor for embolic events.
Conclusions: Patients with LVRR experience higher incidence of LVT resolution and have lower risk of embolic events, highlighting the significance of identifying and mitigating risk factors that contribute to abnormal LV function and structure in management of patients with LVT.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11287347 | PMC |
| http://dx.doi.org/10.1002/ehf2.14781 | DOI Listing |
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