Results of this study demonstrate that a dose of 75 mg/kg of chloral hydrate supplemented by nitrous oxide is superior to the dose of 50 mg/kg, for behavior management of young children sedated for dental treatment.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Comparative Analysis of Preoperative Sedation Modalities: Oral Midazolam and Ketamine Versus Chloral Hydrate and Meperidine in Pediatric Tonsillectomy - A Randomized Clinical Trial.
Turk Arch Otorhinolaryngol
January 2025
Shiraz University of Medical Sciences, Anesthesiology and Critical Care Research Center, Shiraz, Iran.
Objective: A pre-anesthetic medication that is ideal for pediatric patients undergoing tonsillectomy should alleviate pediatric anxiety, facilitate the smooth induction of anesthesia, and have an analgesic effect for postoperative care. This study compared the effectiveness of an oral combination of midazolam and ketamine (MK) with an oral combination of chloral hydrate and meperidine (CM) as premedication in pediatric patients undergoing tonsillectomy.
Methods: This double-blind clinical trial study was conducted with 68 pediatric patients scheduled to undergo tonsillectomy.
When patients with Creutzfeldt-Jakob disease are misdiagnosed as having nonconvulsive status epilepticus.
Epilepsia
January 2025
Epilepsy Unit, Hôpital Gui de Chauliac, Montpellier, France.
Contemporary studies report nonconvulsive status epilepticus (NCSE) in Creutzfeldt-Jakob disease (CJD), based on benzodiazepine (BZP)-responsive epileptiform discharges on the electroencephalogram (EEG), with the following false syllogism: (1) intravenous (IV) administration of BZPs usually suppress ictal activity in NCSE; (2) in CJD, periodic sharp wave complexes (PSWCs) are suppressed by IV BZPs; (3) therefore, these patients have NCSE. This is a simplistic and invalid conclusion, because authors of 20th-century science reports have clearly shown that IV BZPs, short-acting barbiturates, and drugs with no antiseizure effects, such as chloral hydrate and IV naloxone, suppress PSWCs, but patients fall asleep with no clinical improvement. In contrast, IV methylphenidate transiently improves both the EEG and clinical states.
View Article and Find Full Text PDFThe impact of ciliary length on the mechanical response of osteocytes to fluid shear stress.
Nitric Oxide
December 2024
Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Key Laboratory of Innovation and Transformation of Advanced Medical Devices, Ministry of Industry and Information Technology, National Medical Innovation Platform for Industry-Education Integration in Advanced Medical Devices (Interdiscipline of Medicine and Engineering), School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. Electronic address:
Background: Osteocytes are crucial for detecting mechanical stimuli and translating them into biochemical responses within the bone. The primary cilium, a cellular 'antenna,' plays a vital role in this process. However, there is a lack of direct correlation between cilium length changes and osteocyte mechanosensitivity changes.
View Article and Find Full Text PDFArticle Synopsis
- Chloral hydrate is a sedative used mainly in children for procedures like dental sedation and can be adapted for different patient needs due to a lack of commercially available age-appropriate forms.
- Researchers created a customizable oral liquid formulation of chloral hydrate using a suspending vehicle called PCCA SuspendIt, which is free from sugar, dyes, and gluten, to improve dosing accuracy for both pediatric and adult patients.
- The study aimed to develop and validate a stability-indicating assay using ultra-high-performance liquid chromatography (UPLC) to ensure the chemical stability of chloral hydrate at varying concentrations.
The Application of Sleep Deprivation Combined With Chloral Hydrate on Pediatric Dermatological Surgery.
Dermatol Surg
November 2024
Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an.
Background: In small dermatological surgeries for infant and child patients, it is required that the child be in a quiet state. However, general anesthesia not only requires the participation of professional anesthesiologists for surgery but also has a high cost and anesthesia risks. Parents have a low acceptance rate.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!