Hypertension can cause hearing loss, but there is no clear definition of the mechanism(s) involved. The study aimed to explore the role of vascular endothelial dysfunction in hypertension with hearing loss. Patients with hypertension were divided into two groups based on hearing loss. Pure tone audiometry (PTA) and endothelial function testing were performed. A total of 216 (432 ears) hypertensive patients were divided into hypertension with hearing loss group (n = 104) and hypertension without hearing loss group (n = 112). The vascular endothelial biomarkers, ET-1 (endothelin-1) and vWF (von Willebrand factor) were significantly higher ( < .05) in the hypertension with hearing loss group. RHI (reactive hyperemia index), ET-1, and vWF were the factors related to hearing loss. The area under the receiver operating characteristic (ROC) curve (AUC) of RHI in the diagnosis of hypertension with hearing loss was .652 (95% CI .552-.751, = .005), and the Youden index was 26.2%. The AUC of ET-1 was .706 (95% CI .612-.799, = .001), and the Youden index was 38.9%. The AUC of vWF was .617 (95% CI .512-.721, = .003), and the Youden index was 28.1%. Vascular endothelial dysfunction may play a role in the pathogenesis of hypertension with hearing loss.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/00033197241247076 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Understanding Parental Perspectives on Childhood Hearing Impairment and Timely Interventions.
Cureus
January 2025
College of Medicine, Department of Otolaryngology - Head and Neck Surgery, University of Jeddah, Jeddah, SAU.
Objectives: Hearing impairment during childhood is a widespread health issue. Prompt recognition and timely intervention are vital for the advancement of language skills. Insufficient parental knowledge can lead to a delay in diagnosing and treating a condition, which can have a negative impact on academic performance.
View Article and Find Full Text PDFCochlear Organ Dissection, Immunostaining, and Confocal Imaging in Mice.
Bio Protoc
January 2025
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
The organ of Corti, located in the inner ear, is the primary organ responsible for animal hearing. Each hair cell has a V-shaped or U-shaped hair bundle composed of actin-filled stereocilia and a kinocilium supported by true transport microtubules. Damage to these structures due to noise exposure, drug toxicity, aging, or environmental factors can lead to hearing loss and other disorders.
View Article and Find Full Text PDFSilent Hearing Loss in Kidney Transplant Patients Receiving Tacrolimus: A Fact or a Myth?
Indian J Nephrol
June 2024
Mansoura Nephrology and Dialysis Unit, Department of Internal Medicine, Mansoura, Egypt.
Background: It has been claimed that tacrolimus may have harmful effects on the auditory system, where it has been linked to ototoxicity and sensorineural hearing loss (SNHL). We evaluated silent SNHL in kidney transplant recipients (KTRs) receiving tacrolimus and the different factors affecting it compared to healthy controls.
Materials And Methods: In this case control study, hearing functions were studied in 42 KTRs receiving tacrolimus as maintenance immunosuppressive therapy for more than 3 months in comparison to 27 age- and gender-matched healthy subjects using tympanometry, pure-tone audiometry (PTA), extended high frequency audiometry (EHFA), and transient evoked oto-acoustic emissions (TEOAEs).
The Efficacy of Platelet-Rich Plasma in the Repair of Tympanic Membrane Perforation.
Int Arch Otorhinolaryngol
January 2025
Department of Ear, Nose and Throat, JJM Medical College, Davangere, Karnataka, India.
Platelet-rich plasma (PRP) contains high platelet concentration and growth factors that help in rapid wound healing, hemostasis, and decreased scarring. It has been used in various conditions to aid in healing, but its use in ear, nose, and throat (ENT) is not yet common. To compare the outcome of using PRP with myringoplasty with that of myringoplasty alone in the repair of tympanic membrane perforations.
View Article and Find Full Text PDFEpidemiological Characteristics and Maternal Risk Factors of Microtia and Aural Atresia in Kazakhstan.
Int Arch Otorhinolaryngol
January 2025
School of Medicine, Nazarbayev University, Astana, Kazakhstan.
Microtia and aural atresia present congenital ear anomalies that affect external ear and are associated with conductive hearing loss. Both anomalies result from exposure to various prenatal risk factors, most common during the first trimester of pregnancy. This study was aimed at epidemiological analysis of microtia/atresia and associated risk factors in the Kazakhstani population.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!