Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones.

Org Biomol Chem

National Research Centre for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang, 330022, China.

Published: May 2024

An efficient electrochemical nickel-catalyzed cross-coupling reaction has been reported here for the synthesis of -glycosides from preactivated phenols and ketones under mild conditions. Various glycosyl thiols, including unprotected sugar, and a diverse range of aryl/alkenyl triflates, including some complex biorelevant phenols and ketones, were well tolerated in this method.

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http://dx.doi.org/10.1039/d4ob00442fDOI Listing

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