This study uses qualitative storytelling methodology to explore the culturally responsive practices of five educators in Hawai'i. Part of a larger study on a place-based resilience and sustainability graduate certificate program at The University of Hawai'i at Mānoa, more broadly, we trace how their experiences as kumu both shape the program and are shaped by it. Their expertise and practices provide actionable examples of how responsive educational approaches, rooted in cultural practice, place, and community, can transform educational experiences for historically marginalized students and communities.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124931 | PMC |
http://dx.doi.org/10.1007/s42822-023-00127-4 | DOI Listing |
Sci Rep
January 2025
Division of Microbiology, National Center for Toxicological Research, Food and Drug Administration (FDA), Jefferson, AR, U.S.A.
Infections associated with urinary catheters are often caused by biofilms composed of various bacterial species that form on the catheters' surfaces. In this study, we investigated the intricate interplay between Escherichia coli and Enterococcus faecalis during biofilm formation on urinary catheter segments using a dual-species culture model. We analyzed biofilm formation and global proteomic profiles to understand how these bacteria interact and adapt within a shared environment.
View Article and Find Full Text PDFDiabetologia
January 2025
Kidney Transplantation Center, Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Aims/hypothesis: Diabetic kidney disease (DKD) features intrarenal inflammation, in which T cells play a part. Hypoxia-inducible factor-1α (HIF-1α), a key transcription factor regulating cellular responses to hypoxia, is reportedly involved in the course of inflammation. The role of HIF-1α in DKD has been investigated, but the conclusions are controversial so far.
View Article and Find Full Text PDFJ Transl Med
January 2025
Aerospace Medical Center, Aerospace Center Hospital, Beijing, China.
Heart-on-a-chip (HoC) devices have emerged as a powerful tool for studying the human heart's intricate functions and dysfunctions in vitro. Traditional preclinical models, such as 2D cell cultures model and animal model, have limitations in accurately predicting human response to cardiovascular diseases and treatments. The HoC approach addresses these shortcomings by recapitulating the microscale anatomy, physiology, and biomechanics of the heart, thereby providing a more clinically relevant platform for drug testing, disease modeling, and personalized therapy.
View Article and Find Full Text PDFDrug Metab Dispos
January 2025
Javelin Biotech, Inc, Woburn, Massachusetts. Electronic address:
Polypharmacy-related drug-drug interactions (DDIs) are a significant and growing healthcare concern. An increasing number of therapeutic drugs on the market underscores the necessity to accurately assess new drug combinations during preclinical evaluation for DDIs. In vitro primary human hepatocytes (PHH) models are only applicable for short-term induction studies because of their rapid loss of metabolic function.
View Article and Find Full Text PDFThe five-item World Health Organization Well-Being Index (WHO-5) is among the most frequently used brief standard measures to assess hedonic well-being. Numerous studies have investigated different facets of its psychometric properties in adult populations. However, whether these results apply to adolescents is uncertain, and only few psychometric studies employed adolescent populations.
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