Purpose: To determine the relationship between the genotypes of the TaqI polymorphism of gene and the clinical forms of COVID-19 in Cuban patients.
Methods: TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19.
Results: There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243-17.842], even severe [OR = 1.200, 95% CI: 0.217-6.638], related to the tt genotype.
Conclusion: There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the gene in the studied Cuban patients.
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http://dx.doi.org/10.1186/s43042-021-00206-4 | DOI Listing |
Children (Basel)
December 2024
Department of Pedodontics, Faculty of Dentistry, Ege University, Izmir 35040, Turkey.
Background/objectives: Vitamin D helps the mineralization of bone, teeth, and other calcified tissues by regulating calcium-phosphate metabolism. The nuclear activation of the vitamin D receptor () gene is essential for the effectiveness of vitamin D. The main objective of this study is to determine the role of vitamin D levels and gene variants in dental caries.
View Article and Find Full Text PDFGinekol Pol
January 2025
Department of Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, Poland, Poland.
Objectives: Hyperandrogenism is a frequently recognized endocrine imbalance in which there is excessive production of androgens. The purpose of the study was to investigate the impact of vitamin D receptor (VDR) gene polymorphisms on chosen bone metabolism and biochemical parameters in women with hyperandrogenism.
Material And Methods: Eighty young females with hyperandrogenism were enrolled in the study, in whom selected parameters of bone turnover, endocrine and metabolic parameters were determined.
Reprod Biomed Online
September 2024
UMF Iuliu Haţieganu, Cluj-Napoca, Romania.
Research Question: Are the combined genotypes and haplotypes of vitamin D receptor (VDR) gene polymorphisms (FokI, ApaI and TaqI) associated with susceptibility to polycystic ovary syndrome (PCOS) and metabolic features of the disease?
Design: This case-control study included 46 women with PCOS and 48 controls. Genotypes of the VDR gene were determined using the polymerase chain reaction-restriction fragment length polymorphism method. Waist circumference, and parameters of lipid and glucose metabolism were evaluated in all women.
PLoS One
December 2024
Department of Cardiology and Vascular Medicine, Faculty of Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia.
The association between Vitamin D Receptor (VDR) gene polymorphisms and essential hypertension (EH) remains controversial. We searched databases (Cochrane Library, EBSCO, EMBASE, LILACS, ProQuest, PubMed, Science Direct, Springer) for studies on VDR gene polymorphisms and EH until May 30, 2024, following PRISMA guidelines. RevMan 5.
View Article and Find Full Text PDFJ Nutr Sci
December 2024
Department of Chemical Pathology, National Health Laboratory Services (NHLS), Johannesburg, South Africa.
Polymorphisms in the vitamin D receptor (VDR) gene (BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236)) and low vitamin D concentrations have previously been associated with type 1 diabetes (T1D). Vitamin D is thought to mediate the switch from a pro-inflammatory Th1 response to an anti-inflammatory Th2 response which is protective against the development of T1D. These associations are inconsistent across studies and population groups.
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