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Brain aging and rejuvenation at single-cell resolution.
Neuron
January 2025
Department of Genetics, Stanford University, Stanford, CA, USA; Glenn Center for the Biology of Aging, Stanford University, Stanford, CA, USA; Wu Tsai Neurosciences Institute, Stanford University, Stanford, CA, USA. Electronic address:
Brain aging leads to a decline in cognitive function and a concomitant increase in the susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. A key question is how changes within individual cells of the brain give rise to age-related dysfunction. Developments in single-cell "omics" technologies, such as single-cell transcriptomics, have facilitated high-dimensional profiling of individual cells.
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Arterioscler Thromb Vasc Biol
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Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, UK.
Bridging sleep with psychiatric disorders through genetics.
Sleep
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Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Lost in the Woods: Spatially Miscomputing Dendritic Trees.
Epilepsy Curr
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Department of Neurology, Massachusetts General Hospital, Harvard Medical School.
Bringing Imaging Biomarkers Into Clinical Reality in Psychiatry.
JAMA Psychiatry
November 2024
Department of Psychiatry and Behavioral Sciences, University of California, San Francisco.
Importance: Advancing precision psychiatry, where treatments are based on an individual's biology rather than solely their clinical presentation, requires attention to several key attributes for any candidate biomarker. These include test-retest reliability, sensitivity to relevant neurophysiology, cost-effectiveness, and scalability. Unfortunately, these issues have not been systematically addressed by biomarker development efforts that use common neuroimaging tools like magnetic resonance imaging (MRI) and electroencephalography (EEG).
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