AI Article Synopsis
- * A total of 42 ST38 isolates were found to carry the NDM-5 gene on their chromosomes, exhibiting virulence traits like biofilm formation, which indicates their persistence.
- * Genomic analysis revealed minimal variation among isolates, suggesting a clonally driven outbreak that could pose a serious nationwide health threat.
Article Abstract
A 2-year national genomic screening in the Czech Republic identified a notable prevalence of the New Delhi metallo-β-lactamase 5 (NDM-5)-producing sequence type 38 (ST38) in the city of Brno. Forty-two ST38 isolates harbored the gene on the chromosome. Virulence factors confirmed the persistence of these isolates through biofilm formation. Single Nucleotide Polymorphisms (SNPs)-based phylogeny and CRISPR assay typing showed minimal genomic variations, implying a clonally driven outbreak. Results suggest that this high-risk clone may impose a nationwide problem.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11620504 | PMC |
| http://dx.doi.org/10.1128/aac.00133-24 | DOI Listing |
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