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Nanoscale-localized multiplexed biological activation of field effect transistors for biosensing applications.
Nanoscale
October 2024
Department of Electrical and Computer Engineering, Tandon School of Engineering, New York University, Brooklyn, NY, 11201, USA.
The rise in antibiotic-resistant pathogens, highly infectious viruses, and chronic diseases has prompted the search for rapid and versatile medical tests that can be performed by the patient. Field-effect transistor (FET)-based electronic biosensing platforms are particularly attractive due to their sensitivity, fast turn-around time, potential for parallel detection of multiple pathogens, and compatibility with semiconductor manufacturing. However, an unmet critical need is a scalable, site-selective multiplexed biofunctionalization method with nanoscale precision for immobilizing different types of pathogen-specific bioreceptors on individual FETs, preventing parallel detection of multiple targets.
View Article and Find Full Text PDFMyrtleciclib, a CDK4/6/9 Inhibitor for the Treatment of Aggressive Cancers.
Curr Med Chem
September 2024
ViroStatics srl Sassari Italy.
Background: Selective Cyclin-Dependent Kinase 4/6 inhibitors (CDK4/6i) have revolutionized the treatment of breast cancer and have potential in other cancers, being manageable drugs yet with some bone marrow toxicity. Selective CDK9 inhibitors (CDK9i) never advanced into clinical use, partly due to side effects, including gastrointestinal toxicity, and a small window between activity and cytotoxicity, which results in a narrow therapeutic index (TI).
Method: To overcome the drawbacks of CDK4/6 and CDK9 inhibitors, we have developed myrtleciclib, a selective CDK4/6/9 inhibitor with few non-critical molecular off-targets.
Green tea extract reduces viral proliferation and ROS production during Feline Herpesvirus type-1 (FHV-1) infection.
BMC Vet Res
August 2024
Department of Veterinary Medicine and Animals Productions, University of Naples Federico II, Via F. Delpino n. 1, Naples, 80137, Italy.
Background: Feline Herpesvirus type-1 (FHV-1) is a worldwide spread pathogen responsible for viral rhinotracheitis and conjunctivitis in cats that, in the most severe cases, can lead to death. Despite the availability of a variety of antiviral medications to treat this illness, mainly characterized by virostatic drugs that alter DNA replication, their use is often debated. Phytotherapeutic treatments are a little-explored field for FHV-1 infections and reactivations.
View Article and Find Full Text PDFCytokinins Reduce Viral Replication and Alter Plaque Morphology of Frog Virus 3 In Vitro.
Viruses
May 2024
Department of Biology, Trent University, 1600 West Bank Drive, Peterborough, ON K9J 0G2, Canada.
Cytokinins (CKs) are a group of N-substituted signaling molecules whose biosynthesis and metabolism have been documented in all kingdoms of life, including vertebrates. While their biological relevance in vertebrate systems continues to be elucidated, they have broadly been documented with therapeutic effects in exogenous applications. In this study, we evaluated the virostatic potential of four types of CKs including, -isopentenyladenine (iP), -isopentenyladenosine (iPR), -isopentenyladenosine-5'monophosphate (iPMP), and 2-methylthiol--isopentenyladenosine (2MeSiPR) against the ranavirus type species, frog virus 3 (FV3).
View Article and Find Full Text PDFIn Vitro Antiviral Activity of Hyperbranched Poly-L-Lysine Modified by L-Arginine against Different SARS-CoV-2 Variants.
Nanomaterials (Basel)
December 2023
Laboratory of Materials Science and Nanotechnology (LMNT), CR-INSTM, Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
The emergence of SARS-CoV-2 variants requires close monitoring to prevent the reoccurrence of a new pandemic in the near future. The Omicron variant, in particular, is one of the fastest-spreading viruses, showing a high ability to infect people and evade neutralization by antibodies elicited upon infection or vaccination. Therefore, the search for broad-spectrum antivirals that can inhibit the infectious capacity of SARS-CoV-2 is still the focus of intense research.
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