AI Article Synopsis
- - Biologics have improved treatment options for inflammatory disorders like psoriasis, but their effects on immunosuppressed patients, such as organ transplant recipients, remain unclear.
- - A case study of a 29-year-old man with a kidney transplant who developed erythroderma showed positive results with adalimumab after traditional treatments failed.
- - A review of 10 articles suggested that while biologics may help psoriasis in transplant patients, careful consideration is essential, signaling a need for more research on their efficacy and safety.
Article Abstract
Biologics have significantly advanced the treatment of inflammatory disorders, including psoriasis. However, their use in immunosuppressed patients, such as those with solid-organ transplants, is less understood. These patients often face dermatological issues, but inflammatory skin diseases are rare due to their immunosuppressive treatments. Our study aims to assess biologics' effectiveness in such immunocompromised patients. We report a case from our institution of a 29-year-old man with a history of psoriasis, who underwent a kidney transplant and later developed erythroderma. He did not respond to traditional treatments and was successfully treated with adalimumab, leading to the discontinuation of MMF. We also reviewed literature in solid organ transplant patients with psoriasis. Our findings, based on 10 articles, indicate a cautious approach to using biologics in this group, with further research needed for efficacy and safety.
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| http://dx.doi.org/10.1111/ajd.14292 | DOI Listing |
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