AI Article Synopsis
- Macular amyloidosis is a localized skin condition characterized by the buildup of amyloid proteins, leading to dark patches on the skin without affecting the overall immune system.
- It commonly affects young women, particularly in India, often linked to skin friction from scrubbing tools.
- The case discussed involves a 23-year-old female with hyperpigmented patches who lacked typical friction history, prompting further investigation into potential other causes like genetics, infections, and UV exposure; treatment focuses on symptom management rather than a complete cure.
Article Abstract
Macular amyloidosis is primary localized cutaneous amyloidosis (PLCA). It is described by the extracellular accumulation of heterogenic amyloid proteins in the skin that does not affect the systemic immune system, causing hyperpigmented patches. It is a prevalent skin disorder of young female adults, especially in India, since it affects the population with darker skin. History of frictional rub on the skin is typically present, such as using loofah or bathing scrubs or stones. The case presented below is of a 23-year-old female who presented with a hyperpigmented patch on the upper back of both sides and extensor surface of arms and did not have any history of usage of loofah on those areas, compelling us to research more on the other causative factors (genetic predisposition, infectious agents, and UV radiation are probable causative factors) for macular amyloidosis. This condition is not entirely cured; it is managed symptomatically only to improve cosmetic outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11016991 | PMC |
| http://dx.doi.org/10.7759/cureus.56248 | DOI Listing |
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