AI Article Synopsis
- - The study investigates the potential causal relationship between mood disorders and conditions like endometriosis and adenomyosis using Mendelian randomisation techniques on a large dataset of European populations.
- - Results indicate that genetically determined traits associated with mood swings and major depression significantly increase the risk of developing endometriosis and adenomyosis, highlighting a strong connection between mental health and these physical health conditions.
- - The findings emphasize the importance of recognizing and managing mood disorders, as they could contribute to the development of endometriosis and adenomyosis, offering new insights into their underlying causes.
Article Abstract
Background: Many studies have found an association between mood-disorder-related traits and endometriosis and adenomyosis. However, the cause-effect relationship remains unclear.
Aims: We conducted Mendelian randomisation analyses to evaluate any causal relationship between mood disorders and endometriosis as well as different sites of endometriosis.
Method: Summary-level statistics for mood-disorder-related traits and endometriosis (8288 cases, 68 969 controls) in European populations were derived from large-scale data-sets of genome-wide association studies. A two-sample Mendelian randomisation was performed using the inverse-variance weighted and weight median methods. Further sensitivity analyses, including heterogeneity, pleiotropy and leave-one-out analyses, were conducted to test the consistency of the results.
Results: Genetically determined mood swings (odds ratio = 2.557, 95% CI: 1.192-5.483, = 0.016) and major depression (odds ratio = 1.233, 95% CI: 1.019-1.493, = 0.031) were causally associated with an increased risk of endometriosis. Mood swings (odds ratio = 4.238, 95% CI: 1.194-15.048, = 0.025) and major depression (odds ratio = 1.512, 95% CI: 1.052-2.173, = 0.025) were also causally associated with the risk of adenomyosis. Sensitivity analyses confirmed the reliability of the results.
Conclusions: Our results suggest that mood-disorder-related traits increase the risk of endometriosis and adenomyosis. This study provides new insights into the potential pathogenesis of endometriosis and adenomyosis, and highlights the importance of preventing endometriosis and adenomyosis in patients with mood-disorder-related traits.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060071 | PMC |
| http://dx.doi.org/10.1192/bjo.2024.46 | DOI Listing |
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