Introduction: Corneal biomechanics has been implicated in a variety of ocular diseases. The purpose of this study was to evaluate the relationship between the glaucoma and corneal biomechanical properties, and exploring the value of corneal biomechanics in the diagnosis and follow-up of glaucoma diseases.
Methods: We searched studies in PubMed, EMBASE, Web of Science and clinicaltrials.gov., as of October 8, 2022. Only English studies were included, without publication time limit. We also searched the reference lists of published reviews. This meta-analysis was conducted with random-effects models, we used mean difference(MD) to evaluate the outcome, and the heterogeneity was assessed with the I statistic. Subgroup analyses were performed under the appearance of high heterogeneity. We used 11 items to describe the characteristics of included studies, publication bias was performed through the Egger's test. The quality assessment were evaluated by Newcastle-Ottawa Scale(NOS) items.
Results: A total of 27 eligible studies were identified for data synthesis and assessment. The result of meta-analysis showed that in the comparison of included indicators, the corneal biomechanics values of glaucoma patients were statistically lower than those of normal subjects in a similar age range. The covered indicators included central corneal thickness(CCT) (MD = -8.34, 95% CI: [-11.74, -4.94]; P < 0.001), corneal hysteresis(CH)(MD = -1.54, 95% CI: [-1.88, -1.20]; P < 0.001), corneal resistance factor(CRF)( MD = -0.82, 95% CI: [-1.21, -0.44]; P < 0.001), and intraocular pressure(IOP)( corneal-compensated intraocular pressure (IOPcc): MD = 2.45, 95% CI: [1.51, 3.38]; P < 0.001); Goldmann-correlated intraocular pressure (IOPg): MD = 1.30, 95% CI: [0.41, 2.20]; P = 0.004), they all showed statistical difference. While the value of axial length(AL) did not show statistically different(MD = 0.13, 95% CI: [-0.24, 0.50]; P = 0.48).
Conclusion: Corneal biomechanics are associated with glaucoma. The findings can be useful for the design of glaucoma screening, treatment and prognosis.
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http://dx.doi.org/10.1186/s12886-024-03443-4 | DOI Listing |
Cornea
November 2024
Department of Ophthalmology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Purpose: The distinction between pellucid-like keratoconus (PLK) and pellucid marginal corneal degeneration (PMD) based on tomographic examinations is difficult. In this study, corneal tomographic and biomechanical parameters, after classifying PMD and PLK using swept-source optical coherence tomography, were analyzed.
Methods: Diagnoses of PLK and PMD were made using SS-OCT imaging, two groups were formed: PLK (n = 30) and PMD (n = 10).
Sci Rep
December 2024
Imaging, Biomechanics and Mathematical Modelling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India.
An induced cylinder and spherical power after implantation with an extended depth of focus (EDOF) and enhanced monofocal intraocular lens (IOL) could improve distance, intermediate (60 cm) and near (40 cm) visual acuity (VA). In this prospective study, forty eyes with Eyhance EDOF IOL (Johnson and Johnson, USA) and 40 eyes with Vivity EDOF IOL (Alcon Laboratories Inc. USA) were included.
View Article and Find Full Text PDFPain Rep
February 2025
Pain Research Institute, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.
Introduction: Pain phenomenology in patients with fibromyalgia syndrome (FMS) shows considerable overlap with neuropathic pain. Altered neural processing leading to symptoms of neuropathic pain can occur at the level of the spinal cord, and 1 potential mechanism is spinal disinhibition. A biomarker of spinal disinhibition is impaired H-reflex rate-dependent depression (HRDD).
View Article and Find Full Text PDFAm J Ophthalmol
December 2024
Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China; School of Medicine, Nankai University, Tianjin, China; Tianjin Eye Hospital, Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Nankai University Affiliated Ophthalmology Hospital, Tianjin, China; Nankai Eye Institute, Nankai University, Tianjin, China. Electronic address:
Purpose: To analyze the effect of individual parameters on the postoperative refractive outcomes of small incision lenticule extraction in myopic eyes using machine learning methods.
Design: Retrospective Clinical Cohort Study METHODS: We included 477 patients (922 eyes) of small incision lenticule extraction at Tianjin Ophthalmology Hospital and divided the patients into two groups to analyzed the factors affecting postoperative refractive outcomes based on the label of postoperative spherical equivalent (SE) ≤ -0.50D.
Sci Rep
December 2024
Laboratory of Biology, Engineering, and Imaging for Ophthalmology, BiiO, Faculty of Medicine, University of Jean Monnet, 10 rue de la Marandière, 42270, Saint-Priest en Jarez, France.
The cornea, the anterior meniscus-shaped transparent and refractive structure of the eyeball, is the first mechanical barrier of the eye. Its functionality heavily relies on the health of its endothelium, its most posterior layer. The treatment of corneal endothelial cells (CECs) deficiency is allogeneic corneal graft using stored donor corneas.
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