AI Article Synopsis
- Bruton's tyrosine kinase inhibitors (BTKis), like acalabrutinib, are the recommended treatment for chronic lymphocytic leukemia (CLL) but can increase the risk of severe infections.
- A 68-year-old male patient developed multiple types of infections, including bacterial, fungal, and viral, while being treated with acalabrutinib.
- This case highlights a potential pattern of increased infection risk associated with BTKis, particularly suggesting that such risks may be a common side effect of the entire medication class.
Article Abstract
Bruton's tyrosine kinase inhibitors (BTKis) are the preferred treatment for chronic lymphocytic leukemia (CLL). Despite their therapeutic benefits, these targeted agents have been associated with an increased risk of invasive infections. We describe a 68-year-old male who developed multiple bacterial, fungal and viral infections while on treatment with acalabrutinib. To our knowledge, this is the first reported case of concomitant CNS infections with and along with cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) pneumonia while on acalabrutinib. This case adds to the scarce literature of fungal and bacterial infections associated with acalabrutinib, raising the suspicion that infection risk is a medication class effect for BTKis.
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| http://dx.doi.org/10.1177/08971900241247660 | DOI Listing |
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