AI Article Synopsis
- The study investigates the link between perioperative red blood cell transfusions and the risk of postoperative venous thromboembolism through a meta-analysis of 15 studies involving nearly 1.9 million patients.
- The results reveal that transfusions significantly increase the risk of developing venous thromboembolism, with an odds ratio of 1.61, suggesting heightened caution is necessary when administering transfusions.
- Subgroup analyses indicate that factors such as transfusion dose, timing, patient population, and follow-up duration influence this risk, emphasizing the need for careful management and preventive strategies in clinical settings.
Article Abstract
Background: Whether perioperative red blood cell transfusions increases the risk of postoperative venous thromboembolism is controversial and uncertain.We aims to explore the relationship between perioperative red blood cell transfusions and the risk of postoperative venous thromboembolism by conducting a meta-analysis.
Objective: To conduct a meta-analysis to systematically evaluate the relationship between perioperative red blood cell transfusions and the risk of postoperative venous thromboembolism.
Methods: PubMed, Embase, Cochrane, and Web of Science databases were searched to identify studies examining the relationship between perioperative red blood cell transfusions and the risk of postoperative venous thromboembolism. The databases were searched from establishment to August 2023.Two researchers independently screened literature and extracted data according to inclusion and exclusion criteria. Newcastle-ottawa Scale was used for quality assessment. Meta-analysis of data was performed using RevMan 5.4 software.
Results: A total of 15 studies involving 1,880,990 patients were included in this study.Meta-analysis showed that perioperative red blood cell transfusions increased the risk of postoperative venous thromboembolism [OR = 1.61, 95%CI (1.37, 1.89), P < 0.001]. Subgroup analyses showed that the transfusion dose,transfusion timing,study population and follow-up time were closely related to the risk of postoperative venous thromboembolism.
Conclusions: In summary, this meta-analysis demonstrated a significant positive association between perioperative red blood cell transfusions and postoperative venous thromboembolism.Healthcare professionals should pay attention to the influence of blood transfusions on postoperative venous thromboembolism, strengthen management and prevention.
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| http://dx.doi.org/10.1016/j.thromres.2024.03.032 | DOI Listing |
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