AI Article Synopsis
- SARS-CoV-2 infection leads to significant lung issues, particularly acute respiratory distress syndrome (ARDS), characterized by inflammation and alveolar damage.
- The NLRP3 inflammasome causes a cytokine storm, with IL-1 beta being a key cytokine involved in this inflammatory response.
- Anakinra, a powerful drug that inhibits IL-1 beta, is suggested as a treatment option to manage ARDS resulting from COVID-19.
Article Abstract
The outcome of the SARS-CoV-2 (COVID-19) infection fundamentally affects the lung field, causing acute respiratory distress syndrome (ARDS). This process is an inflammatory picture, involving an NLRP3 inflamosome-triggered cytokine storm, the main player in alveolar destruction. IL-1 beta stands out among the cytokines that are triggered in this picture. Anakinra is a potent biological drug, capable of blocking this IL-1ß. We propose its use in controlling ARDS secondary to COVID-19 infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183956 | PMC |
| http://dx.doi.org/10.1016/j.reuma.2020.04.009 | DOI Listing |
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