A Concise Route to Keto-Bridged Polyphenols by Photo-Fries Rearrangement in Flow.

Chem Asian J

Department of Applied Chemistry, National Yang Ming Chiao Tung University, No. 1001 University Road, Hsinchu, 30010, Taiwan.

Published: July 2024

Described is a new synthetic route to bis(2-hydroxy-3,5-di-t-butylphenyl)methanone and its derivatives. The combined esterification/photo-Fries rearrangement approach enables a modular preparation of keto-bridged polyphenols. This protecting group-free process is highly atom- and step-economic, and a scalable production was easily achieved in the continuous-flow mode.

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Source
http://dx.doi.org/10.1002/asia.202400269DOI Listing

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