AI Article Synopsis
- The study investigates the link between exercise and brain-derived neurotrophic factor (BDNF) levels in individuals with overweight and obesity, amid concerns over the cognitive impacts of rising obesity rates.
- A systematic review of 13 studies found no significant effect of exercise on resting BDNF levels, with most studies demonstrating a low risk of bias but showing consistent results across different participant ages and control conditions.
- The authors recommend conducting more rigorous and larger-scale studies to better understand the role of BDNF in cognitive function related to obesity.
Article Abstract
Background: . An explosion in global obesity epidemic poses threats to the healthcare system by provoking risks of many debilitating diseases, including cognitive dysfunction. Physical activity has been shown to alleviate the deleterious effects of obesity-associated cognitive deficits across the lifespan. Given the strong neuroprotective role of brain-derived neurotrophic factor (BDNF) and exercise training as a known modulator for its elevation, this systematic review sought to examine the strength of the association between exercise and BDNF levels in healthy people with overweight and obesity.
Methods: Six electronic databases (PubMed, MEDLINE, EMBASE, Web of Science, Ovid Nursing Database, and SPORTDiscus) were searched from their inceptions through December 2022. The primary outcome of interest was BDNF levels. Interventional studies (randomized and quasi-experimental) with English full text available were included. Risk of bias of the included studies was assessed using the Physiotherapy Evidence Database Scale. Data were extracted for meta-analyses by random-effects models.
Results: Thirteen studies ( = 750), of which 69.2% (9/13) had low risk of bias, were included. In the meta-analysis, exercise interventions had no significant effect on resting BDNF levels (standardized mean difference: -0.30, 95% CI -0.80 to 0.21, = 0.25). Subgroup analyses also indicated no effects of age and types of control groups being compared on moderating the association.
Conclusion: To further inform the role of BDNF in obesity-related cognitive functioning, rigorous studies with larger samples of participants and raw data available were imperatively deserved.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11015502 | PMC |
| http://dx.doi.org/10.1016/j.jesf.2024.04.001 | DOI Listing |
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