AI Article Synopsis
- The text discusses a clinical case of acute calcareous corneal degeneration that occurred in a patient suffering from chronic graft-versus-host disease (cGVHD), a common complication after bone marrow transplants.
- cGVHD affects 50-70% of bone marrow transplant patients and is commonly associated with dry eye issues, specifically keratoconjunctivitis sicca (KCS).
- The paper highlights the rarity of acute calcareous corneal degeneration cases and its potential link to chronic ocular inflammation in individuals with cGVHD.
Article Abstract
To describe acute calcareous corneal degeneration as a complication of chronic graft-versus-host disease. Clinical case and review of the literature. We presented a case of bilateral acute calcareous corneal degeneration in a patient with chronic graft-versus-host disease. Chronic graft-versus-host disease (cGVHD) occurs in 50-70% of bone marrow transplantation patients, the most frequent ocular complication being keratoconjunctivitis sicca (KCS). Calcareous corneal degeneration is a type of calcium deposition that can be secondary to chronic ocular inflammation or dry eye, but there are few cases reported of acute calcareous corneal degeneration and recurrent perforation in cGVHD. GVHD = Chronic graft-versus-host disease, aGVHD = Acute graft-versus-host disease, cGVHD = Chronic graft-versus-host disease, KCS = Keratoconjunctivitis sicca, PKP = Penetrating keratoplasty, AMT = Amniotic membrane transplantation, PRGF = Plasma rich in growth factors, OD = Right eye, OS = Left eye.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007567 | PMC |
| http://dx.doi.org/10.22336/rjo.2024.10 | DOI Listing |
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