MicroRNAs in hepatocellular carcinoma treatment: Charting the path forward.

World J Gastroenterol

Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United States.

Published: March 2024

MicroRNAs (miRNAs) are recognized for their involvement in the regulation of gene expression and exhibit significant potential in both the prognostic assessment and treatment of hepatocellular carcinoma (HCC). HCC, like other tumors, seldom occurs in isolation; instead, it evolves within a microenvironment featuring oncogenic and tumor-suppressive elements. When combined with suitable delivery vehicles, miRNA technology provides the capability to directly engage with these elements, thereby hindering tumor formation and progression. Ongoing research in this domain holds the promise of enabling a more efficacious and multi-modal treatment approach for HCC in the near future.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11008419PMC
http://dx.doi.org/10.3748/wjg.v30.i11.1470DOI Listing

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